(Q39360374)

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Human neural stem cells genetically modified to express human nerve growth factor (NGF) gene restore cognition in the mouse with ibotenic acid-induced cognitive dysfunction

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Europe PubMed Central

PubMed publication ID

11 September 2017

Human neural stem cells genetically modified to express human nerve growth factor (NGF) gene restore cognition in the mouse with ibotenic acid-induced cognitive dysfunction (English)

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Europe PubMed Central

PubMed publication ID

11 September 2017

neural stem cell

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Hong J Lee

1

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Europe PubMed Central

PubMed publication ID

11 September 2017

In J Lim

2

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Europe PubMed Central

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11 September 2017

Seung W Park

3

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Europe PubMed Central

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11 September 2017

Yun B Kim

4

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Europe PubMed Central

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11 September 2017

Yong Ko

5

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Europe PubMed Central

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11 September 2017

Seung U Kim

6

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11 September 2017

publication date

20 April 2012

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Europe PubMed Central

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11 September 2017

Cell Transplantation

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Europe PubMed Central

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11 September 2017

21

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Europe PubMed Central

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11 September 2017

11

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Europe PubMed Central

PubMed publication ID

11 September 2017

2487-2496

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Europe PubMed Central

PubMed publication ID

11 September 2017

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

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Therapeutic potential of CERE-110 (AAV2-NGF): targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons

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Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease.

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Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

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Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

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Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes.

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Stem and progenitor cell-based therapy of the human central nervous system.

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Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair

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Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway

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Human neural stem cells genetically modified for brain repair in neurological disorders

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Stem cell-based cell therapy in neurological diseases: a review

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Production and characterization of immortal human neural stem cell line with multipotent differentiation property

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Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease

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Culture of purified rat astrocytes in serum-free medium supplemented with mitogen

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Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

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The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor

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Nerve growth factor treatment after brain injury prevents neuronal death

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Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model

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Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model

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Human neural stem cells genetically modified to overexpress brain‐derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model

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Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage

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Stem cells for the treatment of neurological disorders

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Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration

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Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain.

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Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment

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Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals.

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Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression

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Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

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NGF-induced remodeling of mature uninjured axon collaterals

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Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

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Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids

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Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma

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Long-term functional restoration by neural progenitor cell transplantation in rat model of cognitive dysfunction: co-transplantation with olfactory ensheathing cells for neurotrophic factor support

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Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury

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Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner.

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Dementia of the Alzheimer Type

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The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

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Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

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Hypophagia is induced by intracerebroventricular administration of nerve growth factor

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AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy

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BDNF improves the effects of neural stem cells on the rat model of Alzheimer's disease with unilateral lesion of fimbria-fornix

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Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease.

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Identifiers

10.3727/096368912X638964

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

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