(Q39376885)

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Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

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Europe PubMed Central

11 September 2017

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition (English)

1 reference

Europe PubMed Central

11 September 2017

author name string

S Cagnol

1

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Europe PubMed Central

11 September 2017

N Rivard

2

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Europe PubMed Central

11 September 2017

language of work or name

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publication date

19 March 2012

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Europe PubMed Central

11 September 2017

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Europe PubMed Central

11 September 2017

32

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Europe PubMed Central

11 September 2017

5

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Europe PubMed Central

11 September 2017

564-576

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Europe PubMed Central

11 September 2017

https://scigraph.springernature.com/pub.10.1038/onc.2012.88

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Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer.

1 reference

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Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells

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Gonadotropin-releasing hormone and protein kinase C signaling to ERK: spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases

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MAP kinase pathways: the first twenty years

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The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

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Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.

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The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade

1 reference

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Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation

1 reference

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Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death.

1 reference

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Spatiotemporal regulation of ERK2 by dual specificity phosphatases

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Seven-transmembrane receptor signalling and ERK compartmentalization.

1 reference

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Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases

1 reference

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Mutations of the BRAF gene in human cancer

1 reference

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KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

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The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity.

1 reference

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The MAPK signalling pathways and colorectal cancer

1 reference

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PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

1 reference

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Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

1 reference

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Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate

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Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellul

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

1 reference

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Phosphorylation of Ser-446 determines stability of MKP-7.

1 reference

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Regulation of MAP kinases by MAP kinase phosphatases.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.88

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Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK.

1 reference

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Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

1 reference

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Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins

1 reference

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Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling

1 reference

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Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells.

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RAS oncogenes: the first 30 years.

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Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation

1 reference

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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MAPK signal specificity: the right place at the right time

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A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.

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Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation

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Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis

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Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature

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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

1 reference

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A novel role for greatwall kinase in recovery from DNA damage

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RAF/RAS oncogenes and mismatch-repair status

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The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

1 reference

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SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein

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Regulation of Ras-MAPK pathway mitogenic activity by restricting nuclear entry of activated MAPK in endoderm differentiation of embryonic carcinoma and stem cells

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KRAS and BRAF: drug targets and predictive biomarkers

1 reference

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Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells

1 reference

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Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

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KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

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Identifiers

10.1038/ONC.2012.88

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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