(Q36111490)

12 August 2017

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title

The MAPK signalling pathways and colorectal cancer (English)

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12 August 2017

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Jing Yuan Fang

1

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PubMed ID

15863380

12 August 2017

Bruce C Richardson

series ordinal

2

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12 August 2017

1 May 2005

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Lancet Oncology Commission

12 August 2017

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12 August 2017

6

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12 August 2017

5

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12 August 2017

322-327

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The genetics of colorectal cancer

12 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

MAP kinases in the immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Development of anticancer drugs targeting the MAP kinase pathway

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https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Therapeutics targeting signal transduction for patients with colorectal carcinoma

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https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

The sevenfold way of PKC regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Integration of multiple downstream signals determines the net effect of insulin on MAP kinase vs. PI 3'-kinase activation: potential role of insulin-stimulated H(2)O(2).

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

The role of mitogen-activated protein (MAP) kinase in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Ternary complex factors: growth factor regulated transcriptional activators

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Prevalence of ras gene mutations in human colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

RAF/RAS oncogenes and mismatch-repair status

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Analysis of signaling protein kinases in human colon or colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Opposing effects of butyrate and bile acids on apoptosis of human colon adenoma cells: differential activation of PKC and MAP kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Mutational analysis of the tyrosine kinome in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Alterations of MAPK activities associated with intestinal cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

Ras/Raf signalling and emerging pharmacotherapeutic targets

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2805%2970168-6

7 January 2021

10.1016/S1470-2045(05)70168-6

Identifiers

DOI

1 reference

12 August 2017

1 reference

PubMed ID

15863380