(Q39377565)

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Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes

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26 January 2020

Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes (English)

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26 January 2020

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26 January 2020

Agueda Gonzalez-rodriguez

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26 January 2020

Isabel Fabregat

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26 January 2020

Patricia Sancho

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26 January 2020

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Conrad Ortiz

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26 January 2020

Laia Caja

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26 January 2020

Ángela M Valverde

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26 January 2020

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16 March 2012

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26 January 2020

Journal of Biological Chemistry

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26 January 2020

287

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26 January 2020

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26 January 2020

15263-15274

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26 January 2020

IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.

1 reference

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11 September 2017

The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells

1 reference

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11 September 2017

In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis

1 reference

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NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

1 reference

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11 September 2017

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

1 reference

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11 September 2017

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

1 reference

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11 September 2017

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

1 reference

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11 September 2017

TGFbeta in Cancer

1 reference

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11 September 2017

Regulation of ROS signal transduction by NADPH oxidase 4 localization

1 reference

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11 September 2017

Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer

1 reference

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Multi-targeted therapy of cancer by genistein

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11 September 2017

Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3

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11 September 2017

Negative regulation of TGF-beta receptor/Smad signal transduction.

1 reference

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11 September 2017

Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins

1 reference

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11 September 2017

Functions and mechanisms of redox regulation of cysteine-based phosphatases

1 reference

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11 September 2017

Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

The role of tyrosine phosphorylation in cell growth and disease

1 reference

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11 September 2017

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

11 September 2017

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

1 reference

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11 September 2017

Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells.

1 reference

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14 September 2017

Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

14 September 2017

NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

14 September 2017

Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

14 September 2017

Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

14 September 2017

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes

1 reference

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14 September 2017

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

14 September 2017

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1 reference

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14 September 2017

Nuclear factor-kappaB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines.

1 reference

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25 September 2017

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1 reference

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15 June 2018

Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

15 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

NGF-activated protein tyrosine phosphatase 1B mediates the phosphorylation and degradation of I-kappa-Balpha coupled to NF-kappa-B activation, thereby controlling dendrite morphology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure

1 reference

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21 August 2018

Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon

1 reference

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21 August 2018

Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3346142

21 August 2018

Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.303958

21 January 2018

Apoptosis Induced by Transforming Growth Factor- in Fetal Hepatocyte Primary Cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal Growth Factor Impairs the Cytochrome C/Caspase-3 Apoptotic Pathway Induced by Transforming Growth Factorβ in Rat Fetal Hepatocytes Via a Phosphoinositide 3-Kinase–Dependent Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.303958

1 reference

Europe PubMed Central

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26 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22427664%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22427664%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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