(Q39389835)

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Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

apoptotic process

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1 reference

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Alfeu Zanotto-Filho

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Ana Maria Oliveira Battastini

3

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Ana Maria Oliveira Battastini

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Elizandra Braganhol

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

José Cláudio Fonseca Moreira

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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publication date

28 February 2012

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

30

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

2252-2262

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.

1 reference

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21 January 2018

Antiproliferative effect of quercetin in the human U138MG glioma cell line

1 reference

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21 January 2018

Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Sensitization of human glioblastomas to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by NF-kappaB inhibitors.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage

1 reference

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21 January 2018

Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Targeted therapies for malignant glioma: progress and potential.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

A survey of glioblastoma genomic amplifications and deletions

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Current and emerging molecular targets in glioma

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

SC68896, a novel small molecule proteasome inhibitor, exerts antiglioma activity in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Bortezomib: a new pro-apoptotic agent in cancer treatment.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Identification of survival genes in human glioblastoma cells by small interfering RNA screening

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-012-9804-Z

21 January 2018

Proteasome inhibition and its therapeutic potential in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NF-kappaB-mediated control of ROS and JNK signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22367315

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-012-9804-Z

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22367315%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

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