(Q39396087)

11 September 2017

title

PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis (English)

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11 September 2017

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5

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7

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Hannele Yki-Järvinen

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Julia Perttilä

1

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Carolina Huaman-Samanez

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2

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Sandrine Caron

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3

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Kimmo Tanhuanpää

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4

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11 September 2017

publication date

14 February 2012

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American Journal of Physiology - Endocrinology and Metabolism

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published in

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11 September 2017

volume

302

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issue

9

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11 September 2017

page(s)

E1063-9

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The natural history of nonalcoholic fatty liver disease: a population-based cohort study

11 September 2017

cites work

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Human fatty liver disease: old questions and new insights

21 January 2018

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Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.

21 January 2018

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The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

A feed-forward loop amplifies nutritional regulation of PNPLA3

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: a study in monozygotic and dizygotic twins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity

21 January 2018

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Adiponutrin gene is regulated by insulin and glucose in human adipose tissue.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Long-term follow-up of patients with nonalcoholic fatty liver

21 January 2018

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

1 reference

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Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

21 January 2018

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Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage

21 January 2018

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I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00125.2011

10.1152/AJPENDO.00125.2011

21 January 2018

Identifiers

DOI

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11 September 2017

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