(Q39396408)

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Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

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Europe PubMed Central

PubMed publication ID

11 September 2017

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells (English)

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Europe PubMed Central

PubMed publication ID

11 September 2017

apoptotic process

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author name string

Jingshu Wang

1

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Europe PubMed Central

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11 September 2017

Xiangsheng Xiao

2

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11 September 2017

Yun Zhang

3

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Europe PubMed Central

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11 September 2017

Dingbo Shi

4

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11 September 2017

Wangbing Chen

5

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Europe PubMed Central

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11 September 2017

Lingyi Fu

6

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Europe PubMed Central

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11 September 2017

Liqun Liu

7

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Europe PubMed Central

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11 September 2017

Fangyun Xie

8

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11 September 2017

Tiebang Kang

9

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11 September 2017

Wenlin Huang

10

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11 September 2017

Wuguo Deng

11

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11 September 2017

publication date

16 February 2012

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11 September 2017

Journal of Pineal Research

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11 September 2017

53

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Europe PubMed Central

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11 September 2017

1

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11 September 2017

77-90

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Europe PubMed Central

PubMed publication ID

11 September 2017

Clinical trials in triple negative breast cancer

1 reference

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Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance

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Targeting IGF-I, IGFBPs and IGF-I receptor system in cancer: the current and future in breast cancer therapy

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HER2 as a target for breast cancer therapy.

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Present and future evolution of advanced breast cancer therapy

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Angiogenesis - still a worthwhile target for breast cancer therapy?

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Melatonin as a cytoskeletal modulator: implications for cell physiology and disease

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Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice

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Melatonin as a natural ally against oxidative stress: a physicochemical examination.

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Melatonin as a free radical scavenger: implications for aging and age-related diseases

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Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer

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Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer

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Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.

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Therapeutic actions of melatonin in cancer: possible mechanisms

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Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

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Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology

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Melatonin sensitizes Caki renal cancer cells to kahweol-induced apoptosis through CHOP-mediated up-regulation of PUMA.

1 reference

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Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway

1 reference

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Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells

1 reference

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Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells

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Involvement of the mt1 melatonin receptor in human breast cancer

1 reference

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Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night

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In vitro and in vivo antitumor activity of melatonin receptor agonists

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Role of cyclooxygenase-2 in colorectal cancer

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Role of cyclooxygenase-2 in breast cancer

1 reference

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Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth

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Cyclooxygenase-2 inhibition in colorectal cancer: boom or bust?

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Apaf-1 is a transcriptional target for E2F and p53

1 reference

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Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line

1 reference

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

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Quantitative analysis of binding of transcription factor complex to biotinylated DNA probe by a streptavidin–agarose pulldown assay

1 reference

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21 January 2018

Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation

1 reference

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21 January 2018

Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding

1 reference

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Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis

1 reference

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An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

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Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation

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Role of p300 and PCAF in regulating cyclooxygenase-2 promoter activation by inflammatory mediators

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Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin

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mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

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Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

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Structure of the apoptotic protease-activating factor 1 bound to ADP

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Molecular mechanisms of caspase regulation during apoptosis

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Identifiers

10.1111/J.1600-079X.2012.00973.X

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

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