(Q39413719)

English

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance

scientific article published on 15 December 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance (English)

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

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1 reference

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inferred from title

Federica Sotgia

6

object named as

Federica Sotgia

1 reference

Europe PubMed Central

11 September 2017

PMC publication ID

Michael P. Lisanti

7

object named as

Michael P Lisanti

1 reference

Europe PubMed Central

11 September 2017

PMC publication ID

Richard Pestell

4

object named as

Richard G Pestell

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Ubaldo E Martinez-Outschoorn

8

object named as

Ubaldo E Martinez-Outschoorn

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Neal Flomenberg

3

object named as

Neal Flomenberg

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

5

object named as

Anthony Howell

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

author name string

Ying-Hui Ko

1

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Zhao Lin

2

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

publication date

15 December 2011

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Cancer Biology and Therapy

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

12

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

12

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

1085-1097

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Ammonia: a diffusible factor released by proliferating cells that induces autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Modulation of intracellular ROS levels by TIGAR controls autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Glutamine in neoplastic cells: focus on the expression and roles of glutaminases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Compartmentation of Glutamine, Glutamate, and GABA Metabolism in Neurons and Astrocytes: Functional Implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Strategies for metabolic exchange between glial cells and neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Transfer of glutamine between astrocytes and neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

A review of cancer cachexia and abnormal glucose metabolism in humans with cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

11 September 2017

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

14 September 2017

Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

25 September 2017

Ammonia derived from glutaminolysis is a diffusible regulator of autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

17 June 2018

Glutamine efflux from astrocytes is mediated by multiple pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

17 June 2018

Glutaminase activities and growth rates of rat hepatomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

17 June 2018

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

17 June 2018

Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

Glucose metabolism in cachectic patients with colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3335942

21 August 2018

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proportionality of glutaminase content to growth rate and morphology of rat neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of tumour bearing on skeletal muscle glutamine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutrition needs of mammalian cells in tissue culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22236876

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CBT.12.12.18671

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

ResearchGate publication ID

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