(Q39431586)

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Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants

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scholarly article

1 reference

Europe PubMed Central

11 September 2017

Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants (English)

1 reference

Europe PubMed Central

11 September 2017

author name string

Bing Liu

1

1 reference

Europe PubMed Central

11 September 2017

Guoyan Geng

2

1 reference

Europe PubMed Central

11 September 2017

Rongtuan Lin

3

1 reference

Europe PubMed Central

11 September 2017

Cuiyan Ren

4

1 reference

Europe PubMed Central

11 September 2017

Jian Hui Wu

5

1 reference

Europe PubMed Central

11 September 2017

publication date

11 January 2012

1 reference

Europe PubMed Central

11 September 2017

Chemical Biology and Drug Design

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Europe PubMed Central

11 September 2017

79

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Europe PubMed Central

11 September 2017

3

1 reference

Europe PubMed Central

11 September 2017

300-312

1 reference

Europe PubMed Central

11 September 2017

Androgen receptors in prostate cancer

1 reference

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21 January 2018

Androgen receptor as a target in androgen-independent prostate cancer

1 reference

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21 January 2018

Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer

1 reference

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Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer

1 reference

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21 January 2018

Androgen receptor action in hormone-dependent and recurrent prostate cancer.

1 reference

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21 January 2018

Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.

1 reference

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21 January 2018

Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

1 reference

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21 January 2018

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Steroid hormone receptors in prostate cancer: a hard habit to break?

1 reference

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21 January 2018

Development of androgen receptor antagonists with promising activity in castration-resistant prostate cancer.

1 reference

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21 January 2018

Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663.

1 reference

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21 January 2018

Androgen receptor: role and novel therapeutic prospects in prostate cancer

1 reference

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21 January 2018

Molecular basis for the antiandrogen withdrawal syndrome.

1 reference

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21 January 2018

Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient

1 reference

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21 January 2018

Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants

1 reference

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21 January 2018

Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance

1 reference

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21 January 2018

Circumventing anti-androgen resistance by molecular design

1 reference

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21 January 2018

NF-kappaB regulates androgen receptor expression and prostate cancer growth

1 reference

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21 January 2018

The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Structural basis for accommodation of nonsteroidal ligands in the androgen receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Structural basis for antagonism and resistance of bicalutamide in prostate cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Comparative protein structure modeling of genes and genomes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

A new test set for validating predictions of protein-ligand interaction.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

WHAT IF: a molecular modeling and drug design program

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Glutamic acid 709 substitutions highlight the importance of the interaction between androgen receptor helices H3 and H12 for androgen and antiandrogen actions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer

1 reference

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21 January 2018

Advances in targeting IKK and IKK-related kinases for cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1747-0285.2011.01290.X

21 January 2018

Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor.

1 reference

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21 January 2018

Identifiers

10.1111/J.1747-0285.2011.01290.X

1 reference

Europe PubMed Central

11 September 2017

1 reference

Europe PubMed Central

11 September 2017

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