(Q44062549)

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Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer.

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10 November 2019

Broadened ligand responsiveness of androgen receptor mutants obtained by random amino acid substitution of H874 and mutation hot spot T877 in prostate cancer (English)

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10 November 2019

prostate cancer

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based on heuristic

inferred from title

4

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10 November 2019

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Karine Steketee

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10 November 2019

Leon Timmerman

2

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10 November 2019

Angelique C J Ziel-van der Made

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10 November 2019

Albert O Brinkmann

5

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10 November 2019

Jan Trapman

6

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10 November 2019

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1 July 2002

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10 November 2019

International Journal of Cancer

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10 November 2019

100

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10 November 2019

309-317

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10 November 2019

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10 November 2019

Androgen-regulated gene expression in prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.10495

21 January 2018

Mechanisms of androgen receptor activation and function.

1 reference

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In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1 reference

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A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

1 reference

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Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer

1 reference

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21 January 2018

A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

1 reference

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21 January 2018

Androgen receptor gene mutations in human prostate cancer

1 reference

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Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome

1 reference

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Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.

1 reference

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Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

1 reference

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21 January 2018

The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens

1 reference

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21 January 2018

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

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A structural role for hormone in the thyroid hormone receptor.

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Molecular basis of agonism and antagonism in the oestrogen receptor

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Atomic structure of progesterone complexed with its receptor

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Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

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The nuclear receptor ligand-binding domain: structure and function.

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Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

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Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

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21 January 2018

Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.

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21 January 2018

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

1 reference

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21 January 2018

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

1 reference

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21 January 2018

Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor

1 reference

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21 January 2018

A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

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21 January 2018

The promoter of the prostate-specific antigen gene contains a functional androgen responsive element

1 reference

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21 January 2018

The human androgen receptor: domain structure, genomic organization and regulation of expression.

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21 January 2018

Improved method for high efficiency transformation of intact yeast cells

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21 January 2018

Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter

1 reference

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21 January 2018

Threonine on amino acid position 868 in the human androgen receptor is essential for androgen binding specificity and functional activity

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21 January 2018

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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21 January 2018

Low incidence of androgen receptor gene mutations in human prostatic tumors using single strand conformation polymorphism analysis

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21 January 2018

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor

1 reference

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21 January 2018

Androgen receptor gene mutations in human prostate cancer

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Steroids of adrenal origin metabolized by human prostatic tissue both in vivo and in vitro.

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Structural invariants in protein folding

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Identifiers

10.1002/IJC.10495

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12115546%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference

Europe PubMed Central

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10 November 2019

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