(Q39433256)

11 September 2017

title

Human phase I vaccine trials of 3 recombinant asexual stage malaria antigens with Montanide ISA720 adjuvant (English)

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11 September 2017

main subject

phase I clinical trial

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1

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Anders RF

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Brown GV

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Lawrence G

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Smillie A

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Rzepczyk CM

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Reed C

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Taylor D

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Anderson K

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Stowers A

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Kemp R

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Allworth A

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Pye D

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Schoofs P

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Irving DO

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Dyer SL

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Woodrow GC

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Briggs WR

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Reber R

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Stürchler D

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11 September 2017

language of work or name

English

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publication date

1 August 1999

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11 September 2017

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11 September 2017

volume

17

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issue

23-24

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11 September 2017

page(s)

3145-3159

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Phase I trial in humans of an oil-based adjuvant SEPPIC MONTANIDE ISA 720.

11 September 2017

cites work

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Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria

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Mapping of the region predominantly recognized by antibodies to the Plasmodium falciparum merozoite surface antigen MSA 1.

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A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

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Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen, PfMSP-1.

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Immunization against the murine malaria parasite Plasmodium yoelii using a recombinant protein with adjuvants developed for clinical use.

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A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

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A second region recognized by the protective monoclonal antibody 5C10/66 in the precursor to the major merozoite surface antigen of Plasmodium chabaudi adami.

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Protection against malaria in Aotus monkeys immunized with a recombinant blood-stage antigen fused to a universal T-cell epitope: correlation of serum gamma interferon levels with protection

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Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1).

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An epitope recognised by inhibitory monoclonal antibodies that react with a 51 kilodalton merozoite surface antigen in Plasmodium falciparum

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Cross-reactivity of antibody against an epitope of the Plasmodium falciparum second merozoite surface antigen

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Structural diversity in the Plasmodium falciparum merozoite surface antigen 2.

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Safety, immunogenicity, and pilot efficacy of Plasmodium falciparum sporozoite and asexual blood-stage combination vaccine in Swiss adults.

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Plasmodium falciparum ring-infected erythrocyte surface antigen is released from merozoite dense granules after erythrocyte invasion

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7 January 2021

Rabbit and human antibodies to a repeated amino acid sequence of a Plasmodium falciparum antigen, Pf 155, react with the native protein and inhibit merozoite invasion

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Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum

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Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria

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7 January 2021

Assessment of the role of naturally acquired antibody levels to Plasmodium falciparum merozoite surface protein-1 in protecting Papua New Guinean children from malaria morbidity

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7 January 2021

Naturally acquired cellular and humoral immune responses to the major merozoite surface antigen (PfMSP1) of Plasmodium falciparum are associated with reduced malaria morbidity.

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7 January 2021

Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area

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7 January 2021

Selection of an adjuvant for vaccination with the malaria antigen, MSA-2.

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7 January 2021

Structure of the RESA gene of Plasmodium falciparum.

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7 January 2021

A simplification of the protein assay method of Lowry et al. which is more generally applicable

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7 January 2021

Kinetic constraints on the development of a malaria vaccine

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7 January 2021

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

1 reference

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7 January 2021

Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages

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7 January 2021

10.1016/S0264-410X(99)00175-9

Identifiers

DOI

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11 September 2017

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