(Q39435736)

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Deletion mutant of human cytomegalovirus lacking US2-US6 and US11 maintains MHC class I expression and antigen presentation by infected dendritic cells

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Europe PubMed Central

PubMed publication ID

11 September 2017

Deletion mutant of human cytomegalovirus lacking US2-US6 and US11 maintains MHC class I expression and antigen presentation by infected dendritic cells (English)

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Europe PubMed Central

PubMed publication ID

11 September 2017

Cytomegalovirus

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Hermann Einsele

6

object named as

Hermann Einsele

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Europe PubMed Central

PubMed publication ID

11 September 2017

author name string

Susanne Schempp

1

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11 September 2017

Max Topp

2

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11 September 2017

Tobias Kessler

3

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Europe PubMed Central

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11 September 2017

Kerstin Laib Sampaio

4

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11 September 2017

Kevin M Dennehy

5

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11 September 2017

Gabriele Hahn

7

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11 September 2017

Götz Ulrich Grigoleit

8

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11 September 2017

Gerhard Jahn

9

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11 September 2017

publication date

21 December 2010

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11 September 2017

number of pages

9

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11 September 2017

155

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11 September 2017

2

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11 September 2017

446-454

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11 September 2017

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process

1 reference

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Infection of dendritic cells by murine cytomegalovirus induces functional paralysis

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Immunobiology of dendritic cells

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Human cytomegalovirus disrupts constitutive MHC class II expression

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Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation

1 reference

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NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulation

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Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells.

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Human cytomegalovirus induces a direct inhibitory effect on antigen presentation by monocyte-derived immature dendritic cells

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Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells

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The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics

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Human cytomegalovirus US2 causes similar effects on both major histocompatibility complex class I and II proteins in epithelial and glial cells

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Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation

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A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

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Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus

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Human cytomegalovirus infection of immature dendritic cells and macrophages

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Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains

1 reference

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Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels

1 reference

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Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes

1 reference

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The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

1 reference

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Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells.

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Immune evasion proteins of human cytomegalovirus do not prevent a diverse CD8+ cytotoxic T-cell response in natural infection

1 reference

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Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway

1 reference

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Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells

1 reference

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Human fibroblasts transfected with cytomegalovirus immediate-early genes show increased MHC class I expression and are targets for natural killer cell-mediated cytotoxicity

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Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain.

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Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy

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Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants

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Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells

1 reference

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Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus

1 reference

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Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83.

1 reference

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Macrophage cultures are susceptible to lytic productive infection by endothelial-cell-propagated human cytomegalovirus strains and present viral IE1 protein to CD4+ T cells despite late downregulation of MHC class II molecules

1 reference

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Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.

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Tissue macrophages are infected by human cytomegalovirus in vivo

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Modification of human cytomegalovirus tropism through propagation in vitro is associated with changes in the viral genome

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Reactivation of latent human cytomegalovirus in CD14(+) monocytes is differentiation dependent

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Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

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Restoration of CD28 expression in CD28- CD8+ memory effector T cells reconstitutes antigen-induced IL-2 production

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Impaired dendritic cell immunophenotype and function in heart transplant patients undergoing active cytomegalovirus infection

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The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

1 reference

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

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Identifiers

10.1016/J.VIRUSRES.2010.11.014

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

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