(Q39437389)

12 September 2017

Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis (English)

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12 September 2017

T Oki

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12 September 2017

J Kitaura

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12 September 2017

N Watanabe-Okochi

3

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12 September 2017

K Nishimura

4

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12 September 2017

A Maehara

5

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12 September 2017

T Uchida

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12 September 2017

Y Komeno

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12 September 2017

F Nakahara

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12 September 2017

Y Harada

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12 September 2017

T Sonoki

10

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12 September 2017

H Harada

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12 September 2017

T Kitamura

12

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12 September 2017

language of work or name

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25 November 2011

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12 September 2017

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12 September 2017

26

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12 September 2017

1038-1045

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12 September 2017

5

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https://scigraph.springernature.com/pub.10.1038/leu.2011.328

12 September 2017

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cites work

Molecular pathogenesis of T-cell leukaemia and lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Activating Notch1 mutations in mouse models of T-ALL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Repressible transgenic model of NRAS oncogene-driven mast cell disease in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Focus on myeloproliferative diseases and myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Digital signaling and hysteresis characterize ras activation in lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Analysis of RAS oncogene mutations in human lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Inherited predispositions and hyperactive Ras in myeloid leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Regulation of Ras in lymphocytes: get a GRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Mast cells in airway hyporesponsive C3H/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Possible involvement of RasGRP4 in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Plat-E: an efficient and stable system for transient packaging of retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Two types of C/EBPα mutations play distinct but collaborative roles in leukemogenesis: lessons from clinical data and BMT models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

Analysis of TCR, pT alpha, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

The role of RasGRPs in regulation of lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

7 January 2021

Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

7 January 2021

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.328

7 January 2021

Identifiers

DOI

10.1038/LEU.2011.328

1 reference

Dimensions Publication ID

12 September 2017

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