(Q39468679)

12 September 2017

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title

Preclinical and clinical development of dexketoprofen (English)

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12 September 2017

Mauleón D

1

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12 September 2017

Artigas R

series ordinal

2

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12 September 2017

García ML

series ordinal

3

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12 September 2017

Carganico G

series ordinal

4

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12 September 2017

publication date

1 January 1996

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12 September 2017

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12 September 2017

volume

52 Suppl 5

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12 September 2017

page(s)

24-45; discussion 45-6

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Pharmacokinetics of ketoprofen enantiomers in cholecystectomy patients: influence of probenecid.

12 September 2017

cites work

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12 December 2020

In vitro fenoprofenyl-coenzyme A thioester formation: interspecies variations

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12 December 2020

Peptic ulcer and gastrointestinal hemorrhage associated with nonsteroidal anti-inflammatory drug use in patients younger than 65 years. A large health maintenance organization cohort study

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12 December 2020

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

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12 December 2020

Double-blind parallel comparison of single oral doses of ketoprofen, codeine, and placebo in patients with moderate to severe dental pain

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12 December 2020

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines

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12 December 2020

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

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12 December 2020

Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen.

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12 December 2020

Interactions of anti-inflammatory 2-arylpropionates (profens) with the metabolism of fatty acids: in vitro studies

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12 December 2020

The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs

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12 December 2020

Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin

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12 December 2020

Ketoprofen in oral surgery pain: a review.

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12 December 2020

The Spinal Actions of Nonsteroidal Anti-Inflammatory Drugs and the Dissociation between their Anti-Inflammatory and Analgesic Effects

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12 December 2020

Activity of nimesulide on constitutive and inducible cyclooxygenases

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12 December 2020

In vitro irreversible binding of ketoprofen glucuronide to plasma proteins

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12 December 2020

Non-steroidal anti-inflammatory drugs associated with gastroduodenal injury and Helicobacter pylori

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12 December 2020

[Biological behavior: serum levels, excretion and biotransformation of (3-benzoylphenyl)-2-propionic acid, or ketoprofen, in animals and men]

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12 December 2020

Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in infants

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12 December 2020

Stereoselectivity of biliary excretion of 2-arylpropionates in rats

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid

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12 December 2020

Mechanisms of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs

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12 December 2020

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

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12 December 2020

Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac

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12 December 2020

Nonsteroidal anti-inflammatory drugs and peptic ulcers: mechanisms, risk factors and treatment

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12 December 2020

Enantiomers in arthritic disorders

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12 December 2020

Pharmacokinetics of ketoprofen enantiomers in healthy subjects following single and multiple doses

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12 December 2020

Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. IV. Ketoprofen disposition

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12 December 2020

Inversion of (R)- to (S)-ketoprofen in eight animal species

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12 December 2020

Antagonism of non-steroidal anti-inflammatory drugs and narcotic analgesics against ethacrynic acid induced writhing

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12 December 2020

Stereoselective disposition of ketoprofen in rats

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12 December 2020

Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

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12 December 2020

A new strategy for the treatment of inflammatory pain. Prevention or elimination of central sensitization

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12 December 2020

Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-inda none (L-745,337), on the cyclo-oxygenase activity of human blood prostagl

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12 December 2020

Non-steroidal anti-inflammatory drugs: how do they damage the gut?

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12 December 2020

The stereoselective uptake of ibuprofen enantiomers into adipose tissue

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12 December 2020

Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs

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12 December 2020

Rationale for the development of stereochemically pure enantiomers: are the R enantiomers of chiral nonsteroidal anti-inflammatory drugs inactive?

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12 December 2020

Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate

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12 December 2020

Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects

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12 December 2020

Bidirectional chiral inversion of the enantiomers of the nonsteroidal antiinflammatory drug oxindanac in dogs

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12 December 2020

Formation of glycine conjugate and (-)-(R)-enantiomer from (+)-(S)-2-phenylpropionic acid suggesting the formation of the CoA thioester intermediate of (+)-(S)-enantiomer in dogs

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12 December 2020

Stereoselective pharmacokinetics of ketoprofen in the rat. Influence of route of administration

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12 December 2020

Endoscopic evaluation of the effect of ketoprofen, ibuprofen and aspirin on the gastroduodenal mucosa

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12 December 2020

Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs

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12 December 2020

The clinical pharmacology of ketoprofen.

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12 December 2020

Xenobiotic acyl-coenzymes A: critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids

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12 December 2020

Inflammatory mediators of pain

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12 December 2020

Clinical pharmacokinetics of ketoprofen and its enantiomers

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12 December 2020

Biological activity of indoprofen and its optical isomers

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12 December 2020

Is there a rational basis for the different spectra of adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs)?

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12 December 2020

Non-steroidal anti-inflammatory drugs and spinal nociceptive processing

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12 December 2020

20 years' experience with ketoprofen

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12 December 2020

The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols

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12 December 2020

Ketoprofen: the European experience

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12 December 2020

New molecules in analgesia

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12 December 2020

Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs

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12 December 2020

Intestinal toxicity of non-steroidal anti-inflammatory drugs

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12 December 2020

Comparison of the safety of several nonsteroidal anti-inflammatory drugs currently or formerly marketed in the United Kingdom.

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12 December 2020

The inhibitory activities of 480156-S and its related compounds on prostaglandin synthetase

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12 December 2020

Moment analysis of stereoselective biliary excretion and chiral inversion of ketoprofen enantiomers in perfused rat liver

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12 December 2020

Stereoselective esterase activity of human serum albumin toward ketoprofen glucuronide

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12 December 2020

NSAIDs: time to re-evaluate gut toxicity

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12 December 2020

Death attributed to antirheumatic medication in a nationwide series of 1666 patients with rheumatoid arthritis who have died

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12 December 2020

Pharmacokinetics of ketoprofen enantiomers in monkeys following single and multiple oral administration

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12 December 2020

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

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12 December 2020

Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test

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12 December 2020

CSM Update: Non-steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions-1

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12 December 2020

Effects of racemic, S- and R-indobufen on cyclooxygenase and lipoxygenase activities in human whole blood

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12 December 2020

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

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12 December 2020

Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs

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12 December 2020

Pharmacokinetics of Ketoprofen Enantiomers in Young and Elderly Arthritic Patients following Single and Multiple Doses

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12 December 2020

Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism

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12 December 2020

The effects of ibuprofen enantiomers on hepatocyte intermediary metabolism and mitochondrial respiration

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12 December 2020

Nonsteroidal anti-inflammatory drugs in perisurgical pain management. Mechanisms of action and rationale for optimum use.

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12 December 2020

Pharmacokinetics and relative bioavailability after single dose administration of 25 mg ketoprofen solution as compared to tablets

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12 December 2020

Pharmacokinetic study of ketoprofen (19.583 R.P.) in man using the tritiated compound

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12 December 2020

Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderly

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12 December 2020

Inhibition of rat peroxisomal palmitoyl-CoA ligase by xenobiotic carboxylic acids

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12 December 2020

The efficacy and safety of ketoprofen in postsurgical dental pain

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12 December 2020

The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis.

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12 December 2020

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

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12 December 2020

Effects of nabumetone on prostanoid biosynthesis in humans.

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12 December 2020

Stereoselective metabolism of anti-inflammatory 2-arylpropionates

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12 December 2020

Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro

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12 December 2020

Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: predisposition to ulceration and relation to Helicobacter pylori.

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12 December 2020

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

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12 December 2020

Enantioselective pharmacodynamics of the nonsteroidal antiinflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity

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12 December 2020

Disposition of ibuprofen in patients with liver cirrhosis. Stereochemical considerations

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12 December 2020

Comparison of parenteral diclofenac and ketoprofen for postoperative pain relief after maxillofacial surgery

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12 December 2020

Diffusion of intramuscular ketoprofen into the cerebrospinal fluid

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12 December 2020

Differential analgesic effects of aspirin-like drugs

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12 December 2020

Covalent binding of suprofen to renal tissue of rat correlates with excretion of its acyl glucuronide

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12 December 2020

The stereospecific inhibition of endogenous triacylglycerol synthesis by fenoprofen in rat isolated adipocytes and hepatocytes

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12 December 2020

[Intestinal complications induced by non-steroidal anti-steroidal anti-inflammatory agents]

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12 December 2020

Enantioselective effects of experimental diabetes mellitus on the metabolism of ibuprofen

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12 December 2020

The (+)-enantiomer is responsible for the antiplatelet and anti-inflammatory activity of (+/-)-indobufen

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12 December 2020

Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy

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12 December 2020

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

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12 December 2020

New insights into the mode of action of anti-inflammatory drugs.

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12 December 2020

Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme

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12 December 2020

Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation

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12 December 2020

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation

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12 December 2020

(-)-R-fenoprofen: formation of fenoprofenyl-coenzyme A by rat liver microsomes

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12 December 2020

Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs

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12 December 2020

Ketorolac penetration into the cerebrospinal fluid of humans

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12 December 2020

The mode of action of anti-inflammatory drugs

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12 December 2020

Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin

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12 December 2020

Plasma protein binding of ketoprofen enantiomers in man: Method development and its application

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12 December 2020

Stereoselective disposition of ibuprofen in patients with compromised renal haemodynamics

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12 December 2020

Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.

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12 December 2020

Ketoprofen enantiomers in synovial fluid

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12 December 2020

Spinal actions of NSAIDS in blocking spinally mediated hyperalgesia: the role of cyclooxygenase products.

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12 December 2020

Correlation between gastric irritancy and anti-inflammatory activity of non-steroidal anti-inflammatory drugs

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12 December 2020

Enantioselective disposition of ibuprofen in elderly persons with and without renal impairment

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12 December 2020

Rectal administration of nonsteroidal antiinflammatory drugs. Effect on rat gastric ulcerogenicity and prostaglandin E2 synthesis.

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12 December 2020

Spinal Cord Effects of Antipyretic Analgesics

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12 December 2020

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

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12 December 2020

Pharmacological aspects of chiral nonsteroidal anti-inflammatory drugs

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12 December 2020

Stereoselective protein binding of ketoprofen: effect of albumin concentration and of the biological system

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12 December 2020

Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro

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12 December 2020

Stereoselective metabolic pathways of ketoprofen in the rat: incorporation into triacylglycerols and enantiomeric inversion

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12 December 2020

Enantioselective aspects of drug action and disposition: therapeutic pitfalls

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12 December 2020

Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen

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12 December 2020

Rac-flurbiprofen is more ulcerogenic than its (S)-enantiomer

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12 December 2020

Drug chirality: on the mechanism of R-aryl propionic acid class NSAIDs. Epimerization in humans and the clinical implications for the use of racemates

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12 December 2020

2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization

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12 December 2020

Central analgesic activity of nonsteroidal antiinflammatory drugs in animal and human pain models

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12 December 2020

The effect of the enantiomers of ibuprofen and flurbiprofen on the beta-oxidation of palmitate in the rat.

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12 December 2020

Stereoselective disposition of ibuprofen and flurbiprofen in rats.

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12 December 2020

Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved

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12 December 2020

Ketoprofen pharmacokinetics in humans: evidence of enantiomeric inversion and lack of interaction

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12 December 2020

Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase

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12 December 2020

Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo

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12 December 2020

[Stereoselective protein binding of non-steroidal anti-inflammatory agents. Pharmacological implications]

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12 December 2020

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat

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12 December 2020

Identifiers

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