(Q36072046)

12 August 2017

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title

Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs (English)

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12 August 2017

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A. M. Evans

1

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PubMed ID

1577041

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1577041

10 October 2022

language of work or name

English

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National Center for Biotechnology Information

PubMed ID

1577041

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1577041

10 October 2022

publication date

1 January 1992

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European Journal of Clinical Pharmacology

12 August 2017

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12 August 2017

42

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12 August 2017

3

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12 August 2017

237-256

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https://scigraph.springernature.com/pub.10.1007/bf00266343

12 August 2017

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12 December 2020

A model for the prostaglandin synthetase cyclooxygenation site and its inhibition by antiinflammatory arylacetic acids

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12 December 2020

Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen.

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12 December 2020

Interrelationships between xenobiotic metabolism and lipid biosynthesis

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12 December 2020

Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition

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12 December 2020

Metabolic chiral inversion of anti-inflammatory 2-arylpropionates: lack of reaction in liver homogenates, and study of methine proton acidity

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12 December 2020

The pharmacokinetics of the enantiomers of flurbiprofen in patients with rheumatoid arthritis

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12 December 2020

Inversion of optical configuration of alpha-methylfluorene-2-acetic acid (cicloprofen) in rats and monkeys

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12 December 2020

Inhibition of prostaglandin biosynthesis by clidanac and related compounds: structural and conformational requirements for PG synthetase inhibition

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12 December 2020

Pharmacokinetic drug interactions with nonsteroidal anti-inflammatory drugs

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in synovial fluid

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12 December 2020

Metabolic chiral inversion of ibuprofen in isolated rat hepatocytes

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12 December 2020

The disposition of ketoprofen enantiomers in man

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12 December 2020

Importance of drug enantiomers in clinical pharmacology

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12 December 2020

Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage

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12 December 2020

Disposition and irreversible plasma protein binding of tolmetin in humans

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12 December 2020

Structure Activity Relationship Among 6-Substituted-2-Naphthylacetic Acids: A New Series of Nonsteroidal Anti-inflammatory Agents

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12 December 2020

Biological activities of optical isomers of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).

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12 December 2020

Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo

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12 December 2020

Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. III. Fenoprofen disposition

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12 December 2020

Stereoselective disposition of ibuprofen enantiomers in man

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12 December 2020

Antagonism of slow reacting substance in anaphylaxis (SRS-A) and other spasmogens on the guinea pig tracheal chain by hydratropic acids and their effects on anaphylaxis

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12 December 2020

Stereospecific inversion of configuration of 2-(2-isopropylindan-5-yl)-propionic acid in rats

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12 December 2020

Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac

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12 December 2020

Pharmacokinetic analysis of the enantiomeric inversion of chiral nonsteroidal antiinflammatory drugs.

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12 December 2020

Pharmacokinetics of ketoprofen enantiomers in healthy subjects following single and multiple doses

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12 December 2020

Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region.

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12 December 2020

Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. IV. Ketoprofen disposition

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12 December 2020

Acylation of albumin by 1-O-acyl glucuronides

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12 December 2020

A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory agents

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12 December 2020

Inhibition of prostaglandin synthesis by sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dihydrate (CS-600), a new anti-inflammatory drug, and its active metabolite in vitro and in vivo

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12 December 2020

Stereoselective inversion of (R)-(-)-benoxaprofen to the (S)-(+)-enantiomer in humans

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12 December 2020

Mechanistic studies of the metabolic chiral inversion of (R)-ibuprofen in humans

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12 December 2020

Optical isomerization of R(−)-clidanac to the biologically active S(+)-isomer in guinea-pigs

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12 December 2020

The stereoselective uptake of ibuprofen enantiomers into adipose tissue

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12 December 2020

Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study

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12 December 2020

Pharmacokinetics of ketoprofen in patients with chronic renal failure

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12 December 2020

The mechanisms of action of nonsteroidal antiinflammatory drugs

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12 December 2020

Naproxen pharmacokinetics in the elderly

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12 December 2020

Stereoselective pharmacokinetics of ketoprofen in the rat. Influence of route of administration

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12 December 2020

Naproxen pharmacokinetics in patients with rheumatoid arthritis during active polyarticular inflammation

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12 December 2020

On chiral drug action

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12 December 2020

Effects of salicylates and other nonsteroidal anti-inflammatory drugs on articular cartilage

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12 December 2020

Determination of the (+)- and (-)-enantiomers of pirprofen in human plasma by high-performance liquid chromatography

1 reference

12 December 2020

Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

1 reference

12 December 2020

Biological activity of indoprofen and its optical isomers

1 reference

12 December 2020

Optical inversion of (2R)- to (2S)-isomers of 2-[4-(2-Oxocyclopentylmethyl)-phenyl]propionic acid (loxoprofen), a new anti-inflammatory agent, and its monohydroxy metabolites in the rat

1 reference

12 December 2020

Stereoselective inversion of (R)-fenoprofen to (S)-fenoprofen in humans

1 reference

12 December 2020

The stereospecific incorporation of fenoprofen into rat hepatocyte and adipocyte triacylglycerols

1 reference

12 December 2020

Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

1 reference

12 December 2020

Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs

1 reference

12 December 2020

Enantiospecific formation of fenoprofen coenzyme A thioester in vitro

1 reference

12 December 2020

4- and 5-Aryl-1-naphthaleneacetic acids as antiinflammatory agents

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12 December 2020

Quantitation of dose and concentration-effect relationships for fenclofenac in rheumatoid arthritis

1 reference

12 December 2020

Mechanism of action of nonsteroidal anti-inflammatory agents.

1 reference

12 December 2020

Clinical pharmacology of non-steroidal anti-inflammatory drugs.

1 reference

12 December 2020

Stereoselective arylpropionyl-CoA thioester formation in vitro

1 reference

12 December 2020

The participation of ethyl 4-benzyloxybenzoate (BRL 10894) and other aryl-substituted acids in glycerolipid metabolism

1 reference

12 December 2020

Relationship of serum naproxen concentration to efficacy in rheumatoid arthritis

1 reference

12 December 2020

High-performance liquid chromatographic analysis of the enantiomers of flurbiprofen and its metabolites in plasma and urine

1 reference

12 December 2020

The contribution of enantiomers to variability in response to anti-inflammatory drugs

1 reference

12 December 2020

Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential

1 reference

12 December 2020

Ibuprofen and sulindac kinetics in alcoholic liver disease

1 reference

12 December 2020

The relationship between the pharmacokinetics of ibuprofen enantiomers and the dose of racemic ibuprofen in humans

1 reference

12 December 2020

Stoichiometry and kinetics of the interaction of prostaglandin H synthase with anti-inflammatory agents

1 reference

12 December 2020

Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. I. 2-Phenylpropionic acid disposition.

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of indoprofen in man

1 reference

12 December 2020

Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers

1 reference

12 December 2020

Lipophilic xenobiotic conjugates: the pharmacological and toxicological consequences of the participation of drugs and other foreign compounds as substrates in lipid biosynthesis

1 reference

12 December 2020

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs--1. In vitro studies of ibuprofen and flurbiprofen

1 reference

12 December 2020

Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs

1 reference

12 December 2020

Pharmacokinetics of Ketoprofen Enantiomers in Young and Elderly Arthritic Patients following Single and Multiple Doses

1 reference

12 December 2020

Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of tiaprofenic acid in humans

1 reference

12 December 2020

The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers

1 reference

12 December 2020

Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

1 reference

12 December 2020

Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin

1 reference

12 December 2020

Studies on the metabolism and chiral inversion of ibuprofen in isolated rat hepatocytes.

1 reference

12 December 2020

Plasma protein binding of flurbiprofen: enantioselectivity and influence of pathophysiological status

1 reference

12 December 2020

Determination of the enantiomers of suprofen and [2H3]suprofen in plasma by capillary gas chromatography-mass spectrometry

1 reference

12 December 2020

Nonsteroidal antiinflammatory agents. I. 6-Substituted 2-naphthylacetic acids

1 reference

12 December 2020

The stereoselectivity of drug action

1 reference

12 December 2020

Enantiomeric interaction of flurbiprofen in the rat.

1 reference

12 December 2020

Stereospecific disposition of flunoxaprofen enantiomers in human beings

1 reference

12 December 2020

The stereospecific inhibition of endogenous triacylglycerol synthesis by fenoprofen in rat isolated adipocytes and hepatocytes

1 reference

12 December 2020

The metabolic chiral inversion of 2-phenylpropionic acid in rat, mouse and rabbit

1 reference

12 December 2020

High-performance liquid chromatographic determination of the stereoisomeric metabolites of ibuprofen

1 reference

12 December 2020

The (+)-enantiomer is responsible for the antiplatelet and anti-inflammatory activity of (+/-)-indobufen

1 reference

12 December 2020

Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.

1 reference

12 December 2020

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

1 reference

12 December 2020

Isomeric inversion of ibuprofen (R)-enantiomer in humans

1 reference

12 December 2020

Antiinflammatory activity of some indan-1-carboxylic acids and related compounds

1 reference

12 December 2020

Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities

1 reference

12 December 2020

Stereoselective metabolism of 2-phenylpropionic acid in rat. I. In vitro studies on the stereoselective isomerization and glucuronidation of 2-phenylpropionic acid

1 reference

12 December 2020

Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme

1 reference

12 December 2020

Influence of probenecid on the urinary excretion rates of the diastereomeric benoxaprofen glucuronides

1 reference

12 December 2020

Studies of intramolecular rearrangements of acyl-linked glucuronides using salicylic acid, flufenamic acid, and (S)- and (R)-benoxaprofen and confirmation of isomerization in acyl-linked delta 9-11-carboxytetrahydrocannabinol glucuronide

1 reference

12 December 2020

Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker

1 reference

12 December 2020

Benoxaprofen kinetics in renal impairment

1 reference

12 December 2020

Inhibition of mitochondrial beta-oxidation of fatty acids by pirprofen. Role in microvesicular steatosis due to this nonsteroidal anti-inflammatory drug

1 reference

12 December 2020

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

1 reference

12 December 2020

Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides

1 reference

12 December 2020

[Binding of racemic indoprofen and its enantiomers to human serum albumin]

1 reference

12 December 2020

Ketoprofen enantiomers in synovial fluid

1 reference

12 December 2020

Active Transport of Foreign Pyrimidines across the Intestinal Epithelium

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12 December 2020

Stereospecific inversion of (R)-(-)-benoxaprofen in rat and man

1 reference

12 December 2020

Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver

1 reference

12 December 2020

Stereoselective plasma protein binding of ibuprofen enantiomers

1 reference

12 December 2020

Stereoselective disposition of indoprofen in surgical patients

1 reference

12 December 2020

Enantioselective aspects of drug action and disposition: therapeutic pitfalls

1 reference

12 December 2020

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

1 reference

12 December 2020

Lack of effect of cimetidine on the pharmacokinetics of R(-)- and S(+)-ibuprofen

1 reference

12 December 2020

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

1 reference

12 December 2020

Stereochemical pharmacokinetics of the 2-arylpropionic acid non-steroidal antiinflammatory drug flunoxaprofen in rats and in man.

1 reference

12 December 2020

Stereoselective pharmacokinetics of flurbiprofen in humans and rats

1 reference

12 December 2020

Enantiomer specific pharmacokinetics

1 reference

12 December 2020

Anti-proliferative properties of clozic, A disease-modifying anti-arthritic agent

1 reference

12 December 2020

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates

1 reference

12 December 2020

Enzymatic inversion at saturated carbon: nature and mechanism of the inversion of R(-) p-iso-butyl hydratropic acid

1 reference

12 December 2020

Application of a stereospecific high-performance liquid chromatography assay to a pharmacokinetic study of etodolac enantiomers in humans

1 reference

12 December 2020

Ketoprofen pharmacokinetics in humans: evidence of enantiomeric inversion and lack of interaction

1 reference

12 December 2020

Irreversible binding of zomepirac to plasma protein in vitro and in vivo

1 reference

12 December 2020

Species-dependent enantioselective glucuronidation of three 2-arylpropionic acids. Naproxen, ibuprofen, and benoxaprofen

1 reference

12 December 2020

Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase

1 reference

12 December 2020

Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters

1 reference

12 December 2020

Presystemic and systemic chiral inversion of R-(-)-fenoprofen in the rat

1 reference

12 December 2020

Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.

1 reference

12 December 2020

Substrate specificity and enantioselectivity of arylcarboxylic acid glucuronidation

1 reference

12 December 2020

Recent findings on the pharmacokinetics of non-steroidal anti-inflammatory drugs in synovial fluid

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00266343

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12 August 2017

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PubMed ID

1577041