(Q39475651)

English

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU.

scientific article published on December 2011

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 September 2017

The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

apoptotic process

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based on heuristic

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author name string

Christina Leah B Kline

1

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Rosalyn B Irby

2

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

publication date

1 December 2011

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Europe PubMed Central

PubMed publication ID

12 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

1285-1294

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

https://scigraph.springernature.com/pub.10.1007/s10495-011-0648-3

0 references

Endpoints and surrogate endpoints in colorectal cancer: a review of recent developments

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Cancer-selective apoptotic effects of extracellular and intracellular Par-4.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Protein expression and intracellular localization of prostate apoptosis response-4 (Par-4) are associated with apoptosis induction in nasopharyngeal carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Expression and function of the leucine zipper protein Par-4 in apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

PAR-4 as a possible new target for pancreatic cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Prostate apoptosis response-4 is expressed in normal cholangiocytes, is down-regulated in human cholangiocarcinoma, and promotes apoptosis of neoplastic cholangiocytes when induced pharmacologically

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Transcriptional regulation of pro-apoptotic Par-4 by NF-kappaB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Phosphorylation of Par-4 by protein kinase A is critical for apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Src kinase induces tumor formation in the c-SRC C57BL/6 mouse

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Src activation regulates anoikis in human colon tumor cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Regulation of Akt/PKB activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Activating SRC mutation in a subset of advanced human colon cancers

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zeta

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

The 14-3-3 cancer connection

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

alpha3beta1 integrin promotes cell survival via multiple interactions between 14-3-3 isoforms and proapoptotic proteins

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Diversity in the SH2 domain family phosphotyrosyl peptide binding site

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Inactivation of the Candidate Tumor Suppressor Par-4 in Endometrial Cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-011-0648-3

21 January 2018

Identifiers

10.1007/S10495-011-0648-3

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

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