(Q39476761)

English

Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

scientific article published on October 1998

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scholarly article

1 reference

Europe PubMed Central

12 September 2017

Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6792864&resulttype=core&format=json

12 May 2020

apoptotic process

1 reference

based on heuristic

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author name string

A J Krohn

1

1 reference

Europe PubMed Central

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12 May 2020

E Preis

2

1 reference

Europe PubMed Central

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12 May 2020

J H Prehn

3

1 reference

Europe PubMed Central

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12 May 2020

language of work or name

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publication date

1 October 1998

1 reference

Europe PubMed Central

12 September 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

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12 May 2020

18

1 reference

Europe PubMed Central

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12 May 2020

8186-8197

1 reference

Europe PubMed Central

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12 May 2020

20

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6792864&resulttype=core&format=json

12 May 2020

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Buckminsterfullerenol free radical scavengers reduce excitotoxic and apoptotic death of cultured cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane potential can be determined in individual cells from the nernstian distribution of cationic dyes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: the executioners of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in cerebellar granule neurones: involvement of interleukin-1 beta converting enzyme-like proteases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA-induced superoxide production and neurotoxicity in cultured rat hippocampal neurons: role of mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of vertebrate neuronal death by the crmA gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of CED-3-related cysteine proteases in apoptosis of cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Removal of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases: intracellular signaling by proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics of programmed cell death in the nematode Caenorhabditis elegans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of a Common Pathway of Apoptosis by Staurosporine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the interleukin-1 beta converting enzyme family rescues neurons from apoptotic death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human ICE/CED-3 protease nomenclature

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9763465

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.18-20-08186.1998

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6792864&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6792864&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6792864&resulttype=core&format=json

12 May 2020

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