(Q39484168)

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(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21869839%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

(+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21869839%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

acute promyelocytic leukemia

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Eduardo Magalhães Rego

17

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11 February 2020

Priscila Santos Scheucher

5

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11 February 2020

Roberto P Falcão

13

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11 February 2020

Pier Paolo Pandolfi

15

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11 February 2020

16

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11 February 2020

author name string

G A S dos Santos

1

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11 February 2020

R S Abreu e Lima

2

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11 February 2020

C R Pestana

3

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11 February 2020

A S G Lima

4

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11 February 2020

C H Thomé

6

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11 February 2020

H L Gimenes-Teixeira

7

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11 February 2020

B A A Santana-Lemos

8

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11 February 2020

A R Lucena-Araujo

9

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11 February 2020

F P Rodrigues

10

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11 February 2020

R Nasr

11

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11 February 2020

S A Uyemura

12

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11 February 2020

H de Thé

14

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11 February 2020

publication date

26 August 2011

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11 February 2020

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11 February 2020

26

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11 February 2020

3

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11 February 2020

451-460

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11 February 2020

Acute promyelocytic leukemia: from highly fatal to highly curable

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Alpha-tocopheryl succinate (alpha-TOS) modulates human prostate LNCaP xenograft growth and gene expression in BALB/c nude mice fed two levels of dietary soybean oil.

1 reference

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21 January 2018

Vitamin E succinate decreases lung cancer tumor growth in mice

1 reference

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21 January 2018

Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent

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21 January 2018

PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Steady-state kinetic properties of FoF1-ATPase: the pH effect.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Apoptosis-associated mitochondrial outer membrane permeabilization assays

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Mitochondrial calcium and the permeability transition in cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

α-Tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cell via NF-κB pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Generation of superoxide by the mitochondrial Complex I.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Enhanced antioxidant and cytoprotective abilities of vitamin E succinate is associated with a rapid uptake advantage in rat hepatocytes and mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

The production of reactive oxygen species by complex I.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Mammalian complex I: a regulable and vulnerable pacemaker in mitochondrial respiratory function

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

THE METABOLISM OF TUMORS IN THE BODY

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Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism

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https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Mitochondrial membrane cholesterol, the voltage dependent anion channel (VDAC), and the Warburg effect

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

21 January 2018

Acute promyelocytic leukemia in very elderly patients: still a clinical challenge

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Treatment of elderly adults with acute promyelocytic leukemia: put the pedal to metal

1 reference

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7 January 2021

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inferred from DOI database lookup

Mechanism of alpha-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.216

7 January 2021

based on heuristic

inferred from DOI database lookup

Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model

1 reference

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Resolution of complex II and isolation of succinate dehydrogenase (EC 1.3.99.1)

1 reference

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based on heuristic

inferred from DOI database lookup

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