(Q40184984)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

main subject

cytotoxicity

0 references

reactive oxygen species

1 reference

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Ekhson Holmuhamedov

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Scott H Kaufmann

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

7

Keith C Bible

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

author name string

Son B Le

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

M Katie Hailer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Sarah Buhrow

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Qi Wang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Karen Flatten

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Peter Pediaditakis

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Lionel D Lewis

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Edward A Sausville

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Matthew M Ames

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

John J Lemasters

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

language of work or name

English

0 references

publication date

9 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

24 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

volume

282

1 reference

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24 December 2019

issue

12

1 reference

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24 December 2019

page(s)

8860-8872

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

24 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance

21 January 2018

1 reference

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Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

21 January 2018

1 reference

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Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL

21 January 2018

1 reference

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Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Free radical formation by antitumor quinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Mitochondrial formation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Mitochondria, oxidants, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Deletion of mtDNA disrupts mitochondrial function and structure, but not biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Rad9 protects cells from topoisomerase poison-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Determination of steady-state levels of oxidative DNA base modifications in mammalian cells by means of repair endonucleases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

THE ISOLATION AND CHARACTERIZATION OF SUBCELLULAR COMPONENTS OF THE EPITHELIAL CELLS OF RABBIT SMALL INTESTINE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: catalytic efficiency regulated by substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Requirement for coenzyme Q in plasma membrane electron transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Mitochondrial effects of triarylmethane dyes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Dysfunctional mitochondrial respiration in the wobbler mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Composition, structure, and function of complex III of the respiratory chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Transcriptional profiling identifies altered intracellular labile iron homeostasis as a contributing factor to the toxicity of adaphostin: decreased vascular endothelial growth factor secretion is independent of hypoxia-inducible factor-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Mitochondrial targets of drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611777200

21 January 2018

Identifiers

DOI

10.1074/JBC.M611777200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213201%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference