(Q44675180)

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Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process

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Europe PubMed Central

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5 December 2017

Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process (English)

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Europe PubMed Central

PubMed publication ID

5 December 2017

5

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Paul Dent

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5 December 2017

author name string

Chunrong Yu

1

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5 December 2017

Mohamed Rahmani

2

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5 December 2017

Jorge Almenara

3

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5 December 2017

Edward A Sausville

4

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5 December 2017

Steven Grant

6

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5 December 2017

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publication date

1 February 2004

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5 December 2017

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5 December 2017

23

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5 December 2017

7

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5 December 2017

1364-1376

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Europe PubMed Central

PubMed publication ID

5 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207248

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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

1 reference

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21 January 2018

In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

1 reference

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Mammalian MAP kinase signalling cascades

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21 January 2018

Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb.

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21 January 2018

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

1 reference

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21 January 2018

Cellular survival: a play in three Akts

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21 January 2018

PI3K: downstream AKTion blocks apoptosis

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21 January 2018

Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

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Positive and negative regulation of JNK1 by protein kinase C and p42(MAP kinase) in adult rat hepatocytes

1 reference

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Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways

1 reference

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21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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21 January 2018

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

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21 January 2018

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

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21 January 2018

Tyrosine kinase inhibition: an approach to drug development

1 reference

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21 January 2018

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

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N-acetylcysteine

1 reference

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21 January 2018

Map kinase signaling pathways and hematologic malignancies

1 reference

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Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

1 reference

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21 January 2018

PKB/AKT: functional insights from genetic models

1 reference

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21 January 2018

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

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21 January 2018

A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation

1 reference

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21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

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21 January 2018

Oxidative stress induces DNA fragmentation and caspase activation via the c-Jun NH2-terminal kinase pathway in H9c2 cardiac muscle cells.

1 reference

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21 January 2018

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1 reference

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21 January 2018

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

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Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells

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21 January 2018

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

1 reference

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21 January 2018

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

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ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

1 reference

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Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207248

7 January 2021

based on heuristic

inferred from DOI database lookup

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

1 reference

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7 January 2021

based on heuristic

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Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway.

1 reference

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7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.ONC.1207248

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

ResearchGate publication ID

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