(Q35166852)

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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5 November 2019

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention (English)

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5 November 2019

William Blalock

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5 November 2019

Richard A. Franklin

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5 November 2019

James A. McCubrey

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5 November 2019

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Chang F

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5 November 2019

Steelman LS

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5 November 2019

Lee JT

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5 November 2019

Shelton JG

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5 November 2019

Navolanic PM

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1 July 2003

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5 November 2019

1263-1293

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5 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402945

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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21 January 2018

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

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21 January 2018

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

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21 January 2018

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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21 January 2018

Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family.

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21 January 2018

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

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21 January 2018

Serine/threonine phosphorylation in cytokine signal transduction

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21 January 2018

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

1 reference

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21 January 2018

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

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21 January 2018

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

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21 January 2018

Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

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21 January 2018

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

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21 January 2018

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

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21 January 2018

Kinases: positive and negative regulators of apoptosis.

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21 January 2018

Suppression of apoptosis: role in cell growth and neoplasia

1 reference

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21 January 2018

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

1 reference

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21 January 2018

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

1 reference

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21 January 2018

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

1 reference

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21 January 2018

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

1 reference

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21 January 2018

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

1 reference

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21 January 2018

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

1 reference

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21 January 2018

Mutations of the BRAF gene in human cancer

1 reference

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21 January 2018

Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

1 reference

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21 January 2018

Ras caught in another affair: the exchange factors for Ral.

1 reference

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21 January 2018

Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways

1 reference

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21 January 2018

Ras-induced transformation and signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of the Raf kinase by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

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21 January 2018

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

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21 January 2018

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

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21 January 2018

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

1 reference

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21 January 2018

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1 reference

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21 January 2018

Membrane localization of Raf assists engagement of downstream effectors

1 reference

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21 January 2018

Definition of regions in human c-myc that are involved in transformation and nuclear localization

1 reference

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21 January 2018

Positive and negative regulation of Raf kinase activity and function by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1 reference

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21 January 2018

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

1 reference

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21 January 2018

14-3-3 proteins; bringing new definitions to scaffolding

1 reference

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21 January 2018

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

1 reference

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21 January 2018

Paradoxical activation of Raf by a novel Raf inhibitor

1 reference

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21 January 2018

Discovery of a novel Raf kinase inhibitor

1 reference

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21 January 2018

Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

1 reference

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21 January 2018

Abrogation of c-Raf expression induces apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The ins and outs of Raf kinases

1 reference

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21 January 2018

Raf meets Ras: completing the framework of a signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of Raf-1 activation and signalling by dephosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

To be or not to be: a question of B-Raf?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

1 reference

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21 January 2018

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

1 reference

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21 January 2018

Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain

1 reference

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21 January 2018

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes.

1 reference

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21 January 2018

Protein kinase C isozymes, novel phorbol ester receptors and cancer chemotherapy

1 reference

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21 January 2018

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Biochemical and biological analysis of Mek1 phosphorylation site mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Pharmacological inhibitors of MAPK pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal transduction pathway targets for anticancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal transduction via the MAP kinases: proceed at your own RSK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

1 reference

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21 January 2018

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Alternative effects of RAS and RAF oncogenes on the proliferation and apoptosis of factor-dependent FDC-P1 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Raf-1 protein mediates insulin-like growth factor-induced proliferation of erythroid progenitor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activated Raf-1 causes growth arrest in human small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The regulatory subunit of protein kinase CK2 is a specific A-Raf activator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Difference in the mechanism of interaction of Raf-1 and B-Raf with H-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of Raf-1 by 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Endothelial apoptosis in Braf-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Craf-1 protein kinase is essential for mouse development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Isotype-specific functions of Raf kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Control of development and immunity by rel transcription factors in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

I kappa B proteins: structure, function and regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The IKK complex: an integrator of all signals that activate NF-kappaB?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncogenic Ras enhances NF-kappaB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of c-myc expression by Ras/Raf signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

ATF and Jun transcription factors, acting through an Ets/CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The serum response element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylated CREB binds specifically to the nuclear protein CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RNA helicase A mediates association of CBP with RNA polymerase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone acetylases and deacetylases in cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Ets family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Serum response factor associated ETS proteins: ternary complex factors and PEA3-binding factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The nfkb1 promoter is controlled by proteins of the Ets family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Fli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Raf-1/MEK/ERK pathway regulates the expression of the p21(Cip1/Waf1) gene in chondrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Ets2 transcription factor inhibits apoptosis induced by colony-stimulating factor 1 deprivation of macrophages through a Bcl-xL-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Identification of a cell type-specific enhancer in the distal 5'-region of the platelet-derived growth factor A-chain gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Proteins of the ETS family with transcriptional repressor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal transduction and the Ets family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Net, a new ets transcription factor that is activated by Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Functional analysis of a growth factor-responsive transcription factor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of the p21(Waf1/Cip1) promoter by the ets oncogene family transcription factor E1AF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

AP-1 in mouse development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

AP-1 in cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transformation by ras modifies AP1 composition and activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The mammalian Jun proteins: redundancy and specificity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulatory role of MEF2D in serum induction of the c-jun promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Jun, the oncoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Quick guide. Jnk.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Phosphorylation of c-jun mediated by MAP kinases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Making decisions through Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mechanisms of apoptosis by c-Myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Myc target genes involved in cell growth, apoptosis, and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The role of c-myc in cellular growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Differential modulation of cyclin gene expression by MYC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Participation of cyclin A in Myc-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Myc cooperates with activated Ras to induce the cdc2 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Identification of CDK4 as a target of c-MYC.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Repression of p15INK4b expression by Myc through association with Miz-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc-mediated transformation: the repression connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal transduction through the Ras/Erk pathway is essential for the mycoestrogen zearalenone-induced cell-cycle progression in MCF-7 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Targeted expression of MYCN causes neuroblastoma in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The Max network gone mad.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

MAP kinase binds to the NH2-terminal activation domain of c-Myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappa B subunit-specific regulation of the interleukin-8 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Genomic organization of human and mouse genes for vascular endothelial growth factor C.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

An acute phase response factor/NF-kappa B site downstream of the junB gene that mediates responsiveness to interleukin-6 in a murine plasmacytoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Involvement of Myc targets in c-myc and N-myc induced human tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transcription factors of the NFAT family: regulation and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A T cell-specific enhancer in the interleukin-3 locus is activated cooperatively by Oct and NFAT elements within a DNase I-hypersensitive site.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Identification of transcription factor binding sites important in the regulation of the human interleukin-5 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

p21 gene regulation during enterocyte differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cdc25 cell-cycle phosphatase as a target of c-myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

all-trans-Retinoic acid in the treatment of Kimura's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

In vitro activity of hederacolchisid A1 compared with other saponins from Hedera colchica against proliferation of human carcinoma and melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inhibition of hypochlorous acid-induced cellular toxicity by nitrite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Farnesyltransferase inhibitors: novel compounds in development for the treatment of myeloid malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Current status of clinical trials of farnesyltransferase inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

BAY 43-9006: preclinical data

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

BAY 43-9006: early clinical data in patients with advanced solid malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Antisense therapy in oncology: new hope for an old idea?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The interaction between coumarin drugs and DNA gyrase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A G-CSF receptor-gyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation and functional analysis of Janus kinase 2 in BA/F3 cells using the coumermycin/gyrase B system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Tyrosine kinase inhibitors in the treatment of chronic myeloid leukaemia: so far so good?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

An essential role for Src kinase in ErbB receptor signaling through the MAPK pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein kinase C inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein kinase C inhibitors as novel anticancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The antitumor drug fostriecin induces vimentin hyperphosphorylation and intermediate filament reorganization.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A novel cAMP-stimulated pathway in protein phosphatase 2A activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protective effect of melatonin against nodularin-induced oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ca2+/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Microcystin-induced down-regulation of lymphocyte functions through reduced IL-2 mRNA stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Production and specificity of monoclonal antibodies against nodularin conjugated through N-methyldehydrobutyrine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cyclin G recruits PP2A to dephosphorylate Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Thyrsiferyl 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cytotoxic triterpenoides from Alismatis Rhizoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Effects of sesquiterpenes and triterpenes from the rhizome of Alisma orientale on nitric oxide production in lipopolysaccharide-activated macrophages: absolute stereostructures of alismaketones-B 23-acetate and -C 23-acetate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Genotoxicity of cyanobacterial extracts containing microcystins from Polish water reservoirs as determined by SOS chromotest and comet assay.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: comparisons with protein synthesis inhibitors and microcystins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oral antibiotics with antiinflammatory/ immunomodulatory effects in the treatment of various dermatoses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal transduction--directed cancer treatments

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cross-talk between signalling pathways and the multidrug resistant protein MDR-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of ionomycin-mediated granule release from rat basophil leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Dual regulation of phosphorylation and dephosphorylation of C/EBPbeta modulate its transcriptional activation and DNA binding in response to growth hormone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Nitric oxide inhibits endothelin-1 production through the suppression of nuclear factor kappa B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Possible new role for NF-kappaB in the resolution of inflammation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Dnmt3L is a transcriptional repressor that recruits histone deacetylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone deacetylase inhibitors as new cancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

New agents in cancer clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Molecular cloning and characterization of a novel histone deacetylase HDAC10

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Histone deacetylase as a new target for cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inhibitors of histone deacetylase as new anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The importance of being K-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Oligonucleotide treatment of ras-induced tumors in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RNA interference: genetic wand and genetic watchdog

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RNA interference may be more potent than antisense RNA in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Signaling from Ras to Rac and beyond: not just a matter of GEFs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Small G-protein networks: their crosstalk and signal cascades.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

RhoG signals in parallel with Rac1 and Cdc42

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Integration of MAP kinase signal transduction pathways at the serum response element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

21 January 2018

The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Raf gets it together

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Different effects of various phospholipids on Ki-Ras-, Ha-Ras-, and Rap1B-induced B-Raf activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

A protein kinase C-, Ras-, and RSK2-dependent signal transduction pathway activates the cAMP-responsive element-binding protein transcription factor following T cell receptor engagement

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

An ordered array of cold shock domain repressor elements across tumor necrosis factor-responsive elements of the granulocyte-macrophage colony-stimulating factor promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular pathways linking hypoxia to activation of c-fos and AP-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Myc oncoproteins are phosphorylated by casein kinase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The treatment of patients with disseminated malignant melanoma by vaccination with autologous cell hybrids of tumor cells and dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical Trials in Childhood Acute Lymphoblastic Leukemia: A Common Prognostic Classification and a Common Induction Therapy Are Now Warranted

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Cisplatin and novobiocin in the treatment of non-small cell lung cancer. A Southwest Oncology Group study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell activation via the disialoganglioside GD3: analysis of signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis regulating proteins as targets of therapy for haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Possible allelopathic effects of cyanotoxins, with reference to microcystin-LR, in aquatic ecosystems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The impact of Chagas disease control in Latin America: a review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The presence of Ca2+ channel beta subunit is required for mitogen-activated protein kinase (MAPK)-dependent modulation of alpha1B Ca2+ channels in COS-7 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

The active fraction of plasmatic plasminogen activator inhibitor type 1 as a possible indicator of increased risk for metastatic melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation and structural elucidation of new cyclotetrapeptides, trapoxins A and B, having detransformation activities as antitumor agents.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific oligobodies against ERK-2 that recognize both the native and the denatured state of the protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402945

7 January 2021

based on heuristic

inferred from DOI database lookup

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