(Q34792851)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12191604%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

review article

1 reference

title

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2 (English)

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12 November 2019

7

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12 November 2019

1

Louise N Johnson

1 reference

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12 November 2019

author name string

Erika De Moliner

2

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12 November 2019

Nick R Brown

3

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12 November 2019

Haiwei Song

4

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12 November 2019

David Barford

5

1 reference

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12 November 2019

Jane A Endicott

6

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12 November 2019

publication date

1 February 2002

1 reference

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Pharmacology & Therapeutics

12 November 2019

published in

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12 November 2019

volume

93

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12 November 2019

issue

2-3

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12 November 2019

page(s)

113-124

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The crystal structure of cyclin A

12 November 2019

cites work

1 reference

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7 January 2021

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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7 January 2021

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

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7 January 2021

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

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7 January 2021

Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms

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7 January 2021

Structure-based design of cyclin-dependent kinase inhibitors

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7 January 2021

Crystal structure of cyclin-dependent kinase 2

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7 January 2021

Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A

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7 January 2021

Absolute Configuration of Staurosporine By X-Ray Analysis

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7 January 2021

Analogs of staurosporine: potential anticancer drugs?

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7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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7 January 2021

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

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7 January 2021

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases

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7 January 2021

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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7 January 2021

Structural basis for control by phosphorylation

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7 January 2021

UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

1 reference

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7 January 2021

Purification, characterization, and kinetic mechanism of cyclin D1. CDK4, a major target for cell cycle regulation

1 reference

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7 January 2021

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

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7 January 2021

Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines

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7 January 2021

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

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7 January 2021

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2

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7 January 2021

Chemical inhibitors of cyclin-dependent kinases

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7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

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7 January 2021

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity.

1 reference

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7 January 2021

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

1 reference

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7 January 2021

Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin

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7 January 2021

Structural basis of cyclin-dependent kinase activation by phosphorylation

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7 January 2021

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

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7 January 2021

Preclinical and clinical development of cyclin-dependent kinase modulators

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7 January 2021

Anticancer drug targets: cell cycle and checkpoint control.

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7 January 2021

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2

1 reference

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7 January 2021

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation

1 reference

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7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

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7 January 2021

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

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7 January 2021

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

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7 January 2021

10.1016/S0163-7258(02)00181-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12191604%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference