(Q44452162)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12764369%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia (English)

1 reference

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3 November 2019

11

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3 November 2019

William Blalock

1

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3 November 2019

Richard A. Franklin

7

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3 November 2019

author name string

P M Navolanic

2

1 reference

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3 November 2019

L S Steelman

3

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3 November 2019

J G Shelton

4

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3 November 2019

P W Moye

5

1 reference

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3 November 2019

J T Lee

6

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3 November 2019

A Mirza

8

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3 November 2019

M McMahon

9

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3 November 2019

M K White

10

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3 November 2019

publication date

1 June 2003

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3 November 2019

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3 November 2019

volume

17

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3 November 2019

issue

6

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3 November 2019

page(s)

1058-1067

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

3 November 2019

cites work

1 reference

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The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

21 January 2018

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Kinases: positive and negative regulators of apoptosis.

21 January 2018

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Ceramide regulates cellular homeostasis via diverse stress signaling pathways

21 January 2018

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Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

21 January 2018

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Growth of factor-dependent hemopoietic precursor cell lines

21 January 2018

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Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

21 January 2018

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Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation.

21 January 2018

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Signaling through the hematopoietic cytokine receptors.

21 January 2018

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Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor

21 January 2018

1 reference

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

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Serine/threonine phosphorylation in cytokine signal transduction

21 January 2018

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Suppression of apoptosis: role in cell growth and neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

A novel MPL point mutation resulting in thrombopoietin-independent activation

21 January 2018

1 reference

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The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

21 January 2018

1 reference

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Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

21 January 2018

1 reference

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PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events

21 January 2018

1 reference

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The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

21 January 2018

1 reference

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Bcl-2 phosphorylation required for anti-apoptosis function

21 January 2018

1 reference

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Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

21 January 2018

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Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

1 reference

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A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

N-Methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of n-methyl-D-aspartate and its inhibition by ethanol

21 January 2018

1 reference

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

Noncaspase proteases in apoptosis

21 January 2018

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Programmed cell death regulation: basic mechanisms and therapeutic opportunities

21 January 2018

1 reference

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IL-3 withdrawal activates a CrmA-insensitive poly(ADP-ribose) polymerase cleavage enzyme in factor-dependent myeloid progenitor cells.

21 January 2018

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Cell death beyond apoptosis

21 January 2018

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

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New agents for acute myelogenous leukemia

21 January 2018

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Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

21 January 2018

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Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells

21 January 2018

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Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation

21 January 2018

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

21 January 2018

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Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

21 January 2018

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Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3.

21 January 2018

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Effects of overexpression of the SH2-containing inositol phosphatase SHIP on proliferation and apoptosis of erythroid AS-E2 cells

21 January 2018

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The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

7 January 2021

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402925

7 January 2021

Inhibition of caspase proteases by CrmA enhances the resistance of human leukemic cells to multiple chemotherapeutic agents

1 reference

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7 January 2021

Expression and activity of caspases 1 and 3 in myelodysplastic syndromes

1 reference

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7 January 2021

Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402925

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12764369%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference