(Q34323738)

1 August 2017

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title

Ceramide regulates cellular homeostasis via diverse stress signaling pathways (English)

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1 August 2017

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Ruvolo PP

1

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1 August 2017

publication date

1 August 2001

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1 August 2017

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1 August 2017

volume

15

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1 August 2017

issue

8

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1 August 2017

page(s)

1153-1160

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402197

1 August 2017

exact match

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cites work

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Serine/threonine phosphorylation in cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Functions of ceramide in coordinating cellular responses to stress

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Stress signals for apoptosis: ceramide and c-Jun kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Regulation of ceramide production and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide in the eukaryotic stress response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide inactivates cellular protein kinase Calpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Programmed cell death induced by ceramide

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide activates the stress-activated protein kinases

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Compartmentalization of ceramide signaling: physical foundations and biological effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sphingomyelin and derivatives as cellular signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Involvement of sphingomyelinases in TNF signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide and sphingomyelinases in the regulation of stress responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Neutral sphingomyelinase: past, present and future

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Signalling mechanisms and oxidative stress in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Purification, characterization, and biosynthesis of human acid ceramidase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sphingosine-1-phosphate: signaling inside and out.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Glucosylceramide synthase and glycosphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Accumulation of glucosylceramides in multidrug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Sounding the alarm: protein kinase cascades activated by stress and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Protein kinase Czeta is a negative regulator of protein kinase B activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Kinases: positive and negative regulators of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

The double-stranded RNA-dependent protein kinase PKR: structure and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

PKR; a sentinel kinase for cellular stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Targeting ceramide metabolism--a strategy for overcoming drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402197

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402197

1 reference

Dimensions Publication ID

1 August 2017

1023347617

0 references

1 reference