(Q44419395)

English

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

scientific article published in April 2003

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scholarly article

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3 November 2019

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells (English)

1 reference

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3 November 2019

James A. McCubrey

11

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3 November 2019

William Blalock

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3 November 2019

Richard A. Franklin

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3 November 2019

Linda S Steelman

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Linda S Steelman

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3 November 2019

author name string

John G Shelton

1

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3 November 2019

John T Lee

3

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3 November 2019

Steven L Knapp

4

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3 November 2019

Phillip W Moye

6

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3 November 2019

Steven C Pohnert

8

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3 November 2019

Amer M Mirza

9

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3 November 2019

Martin McMahon

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3 November 2019

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publication date

1 April 2003

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3 November 2019

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3 November 2019

22

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3 November 2019

2478-2492

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3 November 2019

16

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3 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206321

0 references

Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

21 January 2018

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 reference

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21 January 2018

Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors

1 reference

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21 January 2018

Phosphatidylinositol 3' kinase: one of the effectors of Ras.

1 reference

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21 January 2018

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

1 reference

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21 January 2018

PKB/AKT: functional insights from genetic models

1 reference

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21 January 2018

A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

1 reference

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21 January 2018

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

1 reference

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21 January 2018

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

1 reference

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21 January 2018

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

21 January 2018

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

1 reference

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7 January 2021

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Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

1 reference

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7 January 2021

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A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

1 reference

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7 January 2021

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1 reference

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7 January 2021

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Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

1 reference

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7 January 2021

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Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

1 reference

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7 January 2021

based on heuristic

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Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Regulation of Raf-1 activation and signalling by dephosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

1 reference

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7 January 2021

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Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

1 reference

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7 January 2021

based on heuristic

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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

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Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Interactions between Ras and Raf: key regulatory proteins in cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine/threonine phosphorylation in cytokine signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

1 reference

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7 January 2021

based on heuristic

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Steroid receptor fusion proteins for conditional activation of Raf-MEK-ERK signaling pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of Raf-1 by phosphorylation of serine 621.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of B-Raf in Ras-induced Raf-1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

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7 January 2021

based on heuristic

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Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase

1 reference

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Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

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The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206321

7 January 2021

based on heuristic

inferred from DOI database lookup

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