(Q40706864)

22 September 2017

Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2). (English)

1 reference

22 September 2017

Bin Zhang

1

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PubMed ID

12209879

22 September 2017

Robert G Fenton

series ordinal

2

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22 September 2017

1 October 2002

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Journal of Cellular Physiology

22 September 2017

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22 September 2017

193

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22 September 2017

1

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22 September 2017

42-54

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Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

22 September 2017

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

21 January 2018

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

21 January 2018

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Oncogenic kinase signalling

21 January 2018

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p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

21 January 2018

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Increasing complexity of Ras signaling.

21 January 2018

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

21 January 2018

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

21 January 2018

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Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

Signaling by dual specificity kinases

21 January 2018

1 reference

Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells

21 January 2018

1 reference

Cell cycle: routine role for Ras.

21 January 2018

1 reference

Ribosomal S6 kinase signaling and the control of translation

21 January 2018

1 reference

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

1 reference

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

21 January 2018

1 reference

Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia

21 January 2018

1 reference

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

21 January 2018

1 reference

Cytogenetic abnormalities in multiple myeloma

21 January 2018

1 reference

Integration of positive and negative growth signals during ras pathway activation in vivo

21 January 2018

1 reference

Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.

21 January 2018

1 reference

Multiple ras effector pathways contribute to G(1) cell cycle progression

21 January 2018

1 reference

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

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Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 January 2018

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The AKT kinase is activated in multiple myeloma tumor cells

21 January 2018

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

21 January 2018

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Mechanisms of myeloma cell growth control

21 January 2018

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Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

21 January 2018

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Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway.

21 January 2018

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Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.

21 January 2018

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

21 January 2018

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Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

1 reference

Primary structure of BMK1: a new mammalian map kinase

21 January 2018

1 reference

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

21 January 2018

1 reference

Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

21 January 2018

1 reference

Ras versus cyclin-dependent kinase inhibitors

21 January 2018

1 reference

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 January 2018

1 reference

Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor

21 January 2018

1 reference

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

21 January 2018

1 reference

Ras oncogene mutation in multiple myeloma

21 January 2018

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Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

21 January 2018

1 reference

Activation of Jun kinase/stress-activated protein kinase by GTPase-deficient mutants of G alpha 12 and G alpha 13.

21 January 2018

1 reference

Phosphorylation and activation of p70s6k by PDK1

21 January 2018

1 reference

Cell-cycle-dependent translational control

21 January 2018

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Prognostic factors in multiple myeloma

21 January 2018

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Pleckstrin homology domains: a common fold with diverse functions.

21 January 2018

1 reference

Mitogen-activated protein kinases: specific messages from ubiquitous messengers

21 January 2018

1 reference

TOR, a central controller of cell growth

21 January 2018

1 reference

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

Hyperexpression of mitogen-activated protein kinase in human breast cancer

21 January 2018

1 reference

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

21 January 2018

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

21 January 2018

1 reference

Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans

21 January 2018

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Cell cycle-dependent activation of Ras.

21 January 2018

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TOR signalling and control of cell growth

21 January 2018

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

Cellular signaling: pivoting around PDK-1.

21 January 2018

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Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

21 January 2018

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Regulation of transcription by MAP kinase cascades

21 January 2018

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

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Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

21 January 2018

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

1 reference

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

21 January 2018

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

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Tec kinases: a family with multiple roles in immunity

21 January 2018

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STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6.

21 January 2018

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Components of a new human protein kinase signal transduction pathway

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCP.10148

1 reference

22 September 2017

1 reference

PubMed ID

12209879