(Q39486053)

12 September 2017

title

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton (English)

1 reference

12 September 2017

1 reference

ChEBI release 2020-05-28

1 reference

3

0 references

author name string

Nagaratna S Hegde

series ordinal

1

1 reference

12 September 2017

Deborah A Sanders

series ordinal

2

1 reference

12 September 2017

Shankar Balasubramanian

series ordinal

4

1 reference

12 September 2017

language of work or name

1 reference

21 August 2011

1 reference

12 September 2017

1 reference

12 September 2017

volume

3

1 reference

12 September 2017

issue

9

1 reference

12 September 2017

page(s)

725-731

1 reference

https://scigraph.springernature.com/pub.10.1038/nchem.1114

12 September 2017

exact match

0 references

cites work

Chemical genetics: ligand-based discovery of gene function

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Inhibition of transcription factors with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Small molecule modulators of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Regulation of gene expression by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

A complex task? Direct modulation of transcription factors with small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The emerging roles of forkhead box (Fox) proteins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

21 January 2018

Thiopeptide antibiotics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Novel anticancer compounds induce apoptosis in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Discovery of a biologically active thiostrepton fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

FoxM1 is a general target for proteasome inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Antibiotic susceptibility of mammalian mitochondrial translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

A novel mode of FoxM1 regulation: positive auto-regulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

A fluorescent probe for the 70 S-ribosomal GTPase-associated center

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Direct inhibition of hypoxia-inducible transcription factor complex with designed dimeric epidithiodiketopiperazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Cyclin E/Cdk2, P/CAF, and E1A regulate the transactivation of the c-myc promoter by FOXM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

GREB 1 is a critical regulator of hormone dependent breast cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

FOXA1 is a key determinant of estrogen receptor function and endocrine response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Induction of human epithelial stem/progenitor expansion by FOXM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The State of the Art of Chemical Biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

The Structure of Thiostrepton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEM.1114

Over-expression of FoxM1 stimulates cyclin B1 expression

21 January 2018

1 reference

12 December 2020

Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor

1 reference

12 December 2020

Thiostrepton, a new antibiotic. I. In vitro studies

1 reference

12 December 2020

Thiostrepton, a new antibiotic. II. Isolation and chemical characterization

1 reference

12 December 2020

Thiostrepton, a new antibiotic. III. In vivo studies

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEM.1114

1 reference

Dimensions Publication ID

12 September 2017

1031719828

0 references

Fatcat ID

release_fac2vgxcbjae5p4znozd5vaowu

0 references

1 reference