(Q39491080)

12 September 2017

title

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human (English)

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12 September 2017

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1

Laurent Salphati

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12 September 2017

3

Emile G Plise

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12 September 2017

Jodie Pang

2

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12 September 2017

Bilin Chou

4

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12 September 2017

Jason S Halladay

5

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12 September 2017

Alan G Olivero

6

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12 September 2017

Patrick J Rudewicz

7

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12 September 2017

Qingping Tian

8

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12 September 2017

Susan Wong

9

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12 September 2017

Xiaolin Zhang

10

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12 September 2017

language of work or name

English

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publication date

13 August 2011

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12 September 2017

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12 September 2017

volume

41

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12 September 2017

issue

12

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12 September 2017

page(s)

1088-1099

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

12 September 2017

cites work

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https://api.crossref.org/works/10.3109%2F00498254.2011.603386

PTEN and the PI3-kinase pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Prediction of exposure-response relationships to support first-in-human study design

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

Targeting the PI3K signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2011.603386

10.3109/00498254.2011.603386

21 January 2018

Identifiers

DOI

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release_beldioz25vbkflj46qtprbhpva

12 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/beldioz25vbkflj46qtprbhpva

mapped directly with Wikidata item

24 November 2022

based on heuristic

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