(Q39492096)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

title

Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

0 references

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Alexander V Gasparian

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Catherine A Burkhart

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Andrei A Purmal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Leonid Brodsky

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Mahadeb Pal

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Madhi Saranadasa

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Dmitry A Bosykh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Mairead Commane

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Olga A Guryanova

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Srabani Pal

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Alfiya Safina

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Sergey Sviridov

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Igor E Koman

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Jean Veith

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Andrei V Gudkov

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Katerina V Gurova

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

English

0 references

publication date

1 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

10 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

issue

95

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

page(s)

95ra74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

10 February 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6281439/fullTextXML

inferred from PubMed Central ID database lookup

cites work

New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cells

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Inflammation and p53: A Tale of Two Stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

FACT facilitates transcription-dependent nucleosome alteration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

de FACTo nucleosome dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

The FACT chromatin modulator: genetic and structure/function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Stable co-occupancy of transcription factors and histones at the HIV-1 enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Minor groove-binding architectural proteins: structure, function, and DNA recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Systemic chemotherapy induces microsatellite instability in the peripheral blood mononuclear cells of breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

p53 and NF-kappaB crosstalk: IKKalpha tips the balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Phosphorylated intrinsically disordered region of FACT masks its nucleosomal DNA binding elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

A role for SSRP1 in recombination-mediated DNA damage response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Assessment of atypical DNA intercalating agents in biological and in silico systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Toward a greater appreciation of noncovalent chemical/DNA interactions: application of biological and computational approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

The initiation-elongation transition: lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Techniques used to study transcription on chromatin templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Promoter clearance by RNA polymerase II is an extended, multistep process strongly affected by sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Probing the Mechanism of C−H Activation: Oxidation of Methylcubane by Soluble Methane Monooxygenase fromMethylosinus trichosporiumOB3b†

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3002530

Extraction, purification and analysis of histones

21 January 2018

1 reference

12 December 2020

Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells

1 reference

12 December 2020

Overview of resistance to systemic therapy in patients with breast cancer

1 reference

12 December 2020

Comparative viscometric analysis of the interaction of chloroquine and quinacrine with superhelical and sonicated DNA

1 reference

12 December 2020

New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning

1 reference

12 December 2020

Rapid screening of structurally selective ligand binding to nucleic acids

1 reference

12 December 2020

NFkappaB-dependent chemoresistance in solid tumors.

1 reference

12 December 2020

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

12 December 2020

p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation

1 reference

12 December 2020

10.1126/SCITRANSLMED.3002530

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21832239%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

21832239

1 reference