(Q39493701)

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Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody.

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9 February 2020

Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody (English)

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9 February 2020

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Susan T Sharfstein

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9 February 2020

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Hussain Dahodwala

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9 February 2020

Mark Nowey

2

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9 February 2020

Tatyana Mitina

3

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9 February 2020

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6 August 2011

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9 February 2020

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9 February 2020

64

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9 February 2020

1

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9 February 2020

27-41

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Europe PubMed Central

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9 February 2020

Pharmacological significance of glycosylation in therapeutic proteins

1 reference

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12 September 2017

Expression systems for therapeutic glycoprotein production.

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12 September 2017

Development trends for new cancer therapeutics and vaccines.

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12 September 2017

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1 reference

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12 September 2017

The IGF-I signaling pathway

1 reference

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12 September 2017

Downstream processing of monoclonal antibodies--application of platform approaches

1 reference

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12 September 2017

Production of recombinant protein therapeutics in cultivated mammalian cells

1 reference

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12 September 2017

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

1 reference

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12 September 2017

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

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12 September 2017

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

1 reference

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12 September 2017

Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences

1 reference

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12 September 2017

Transcriptomic responses to sodium chloride-induced osmotic stress: a study of industrial fed-batch CHO cell cultures.

1 reference

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14 September 2017

Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling.

1 reference

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14 September 2017

Recombinant insulin-like growth factor-I (IGF-I) production in Super-CHO results in the expression of IGF-I receptor and IGF binding protein 3.

1 reference

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14 September 2017

Isolation, characterization and recombinant protein expression in Veggie-CHO: A serum-free CHO host cell line

1 reference

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14 September 2017

Genome-wide analysis of mouse myeloma cell lines expressing therapeutic antibodies

1 reference

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14 September 2017

Functional genome-wide analysis of antibody producing NS0 cell line cultivated at different temperatures

1 reference

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14 September 2017

Biopharmaceutical benchmarks 2006.

1 reference

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14 September 2017

Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

14 September 2017

Genome-wide analysis of the transcriptional response of murine hybridomas to osmotic shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

14 September 2017

Application of factorial design to accelerate identification of CHO growth factor requirements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

14 September 2017

Methods for growth of cultured cells in serum-free medium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

14 September 2017

Effects of insulin and LongR(3) on serum-free Chinese hamster ovary cell cultures expressing two recombinant proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

25 September 2017

The importance of ammonia in mammalian cell culture

1 reference

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25 September 2017

Intracellular flux analysis in hybridomas using mass balances and in vitro (13)C nmr.

1 reference

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25 September 2017

Chinese hamster ovary cells produce sufficient recombinant insulin-like growth factor I to support growth in serum-free medium. Serum-free growth of IGF-I-producing CHO cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Evidence that phosphatidylcholine-specific phospholipase C is a key molecule mediating insulin-induced enhancement of gene expression from human cytomegalovirus promoter in CHO cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Survival of 3T3 cells expressing or co-expressing bFGF and/or IGF-I and/or IGF-II in low serum and serum free media

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Modeling hybridoma cell metabolism using a generic genome-scale metabolic model of Mus musculus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: an in vivo 13C nuclear magnetic resonance study

1 reference

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17 June 2018

Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor

1 reference

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1 reference

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17 June 2018

Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism

1 reference

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17 June 2018

Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency

1 reference

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17 June 2018

High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker

1 reference

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17 June 2018

Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3261449

17 June 2018

Hormonal growth control of cells in culture

1 reference

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17 June 2018

A flexible state-space approach for the modeling of metabolic networks I: development of mathematical methods.

1 reference

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21 August 2018

A flexible state-space approach for the modeling of metabolic networks II: advanced interrogation of hybridoma metabolism.

1 reference

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21 August 2018

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1 reference

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21 August 2018

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1 reference

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21 August 2018

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21 August 2018

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21 August 2018

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21 August 2018

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21 August 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21822681

12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21822681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factorial designs combined with the steepest ascent method to optimize serum-free media for CHO cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21822681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-I and transferrin mediate growth and survival of Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21822681

12 December 2020

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inferred from PubMed ID database lookup

Discovery and development of biopharmaceuticals: current issues

1 reference

https://pubmed.ncbi.nlm.nih.gov/21822681

12 December 2020

based on heuristic

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10.1007/S10616-011-9388-Z

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Europe PubMed Central

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9 February 2020

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Europe PubMed Central

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9 February 2020

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Europe PubMed Central

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9 February 2020

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