(Q39500669)

English

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Marco Pirazzini

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Ornella Rossetto

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Cesare Montecucco

5

object named as

Cesare Montecucco

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Paolo Bolognese

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Clifford C Shone

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

1 reference

based on heuristic

inferred from title

publication date

25 August 2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Cellular Microbiology

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1731-1743

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21790947%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Very fast prediction and rationalization of pKa values for protein-ligand complexes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Cell entry strategy of clostridial neurotoxins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Tetanus toxin fragment forms channels in lipid vesicles at low pH

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Molecular basis for tetanus toxin coreceptor interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Gangliosides as High Affinity Receptors for Tetanus Neurotoxin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Beyond BOTOX: advantages and limitations of individual botulinum neurotoxins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

SV2 is the protein receptor for botulinum neurotoxin A.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Ion-conducting channels produced by botulinum toxin in planar lipid membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Role of metals in the biological activity of Clostridium botulinum neurotoxins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Single molecule detection of intermediates during botulinum neurotoxin translocation across membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Crucial role of the disulfide bridge between botulinum neurotoxin light and heavy chains in protease translocation across membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxin devoid of receptor binding domain translocates active protease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Role of acidic lipids in the translocation and channel activity of colicins A and N in Escherichia coli cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

N-glycosylation is essential for vesicular targeting of synaptotagmin 1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Sequence homology and structural analysis of the clostridial neurotoxins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Crystal structure of botulinum neurotoxin type A and implications for toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Very fast empirical prediction and rationalization of protein pKa values

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Interaction of tetanus toxin with lipid vesicles. Effects of pH, surface charge, and transmembrane potential on the kinetics of channel formation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxin: a marvel of protein design

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

How do tetanus and botulinum toxins bind to neuronal membranes?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinal neurotoxins: revival of an old killer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Presynaptic receptor arrays for clostridial neurotoxins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Mosaic structures of neurotoxins produced from Clostridium botulinum types C and D organisms

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Concerted protonation of key histidines triggers membrane interaction of the diphtheria toxin T domain.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Comparison of the pH-induced conformational change of different clostridial neurotoxins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Conformational switching of the diphtheria toxin T domain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Presynaptic enzymatic neurotoxins.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Diphtheria toxin entry into cells is facilitated by low pH.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Gating and permeability of ion channels produced by botulinum toxin types A and E in PC12 cell membranes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

TCEP treatment reduces proteolytic activity of BoNT/B in human neuronal SHSY-5Y cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

A 50-kDa fragment from the NH2-terminus of the heavy subunit of Clostridium botulinum type A neurotoxin forms channels in lipid vesicles

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

The role of the interchain disulfide bond in governing the pharmacological actions of botulinum toxin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Internalization and proteolytic action of botulinum toxins in CNS neurons and astrocytes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

SV2 mediates entry of tetanus neurotoxin into central neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Crystal structure of the receptor binding domain of the botulinum C–D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1462-5822.2011.01654.X

21 January 2018

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39500669&oldid=1644946073"