(Q39501601)

12 September 2017

title

JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms (English)

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12 September 2017

6

E Solary

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author name string

M Nakatake

1

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12 September 2017

B Monte-Mor

2

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12 September 2017

N Debili

3

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12 September 2017

N Casadevall

4

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12 September 2017

V Ribrag

5

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12 September 2017

W Vainchenker

7

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12 September 2017

I Plo

8

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12 September 2017

language of work or name

English

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publication date

25 July 2011

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12 September 2017

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12 September 2017

volume

31

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12 September 2017

issue

10

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12 September 2017

page(s)

1323-1333

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https://scigraph.springernature.com/pub.10.1038/onc.2011.313

12 September 2017

exact match

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cites work

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RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes.

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P53 mRNA controls p53 activity by managing Mdm2 functions

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Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells.

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Chromatin structure regulates gene conversion

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

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The prognostic significance of p16(INK4a)/p14(ARF) locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia

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p53 in chronic myelogenous leukemia in acute phase

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Functions of the MDM2 oncoprotein

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Genetic lesions associated with blastic transformation of polycythemia vera and essential thrombocythemia

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Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

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JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

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31 March 2020

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31 March 2020

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice

31 March 2020

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BCR/ABL activates mdm2 mRNA translation via the La antigen

31 March 2020

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N-ras and p53 gene mutations in Japanese patients with myeloproliferative disorders.

31 March 2020

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31 March 2020

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Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

31 March 2020

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Loss of p53 in F-MuLV induced-erythroleukemias accelerates the acquisition of mutational events that confers immortality and growth factor independence

31 March 2020

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Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders

31 March 2020

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Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.313

1 reference

Dimensions Publication ID

12 September 2017

1017507817

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Fatcat ID

release_jnw7c5dvjvanfmrzzfest3ekuq

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1 reference