(Q39510022)

English

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease.

scientific article published on March 1999

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha1 protease inhibitor: implications for the pathogenesis of cystic fibrosis lung disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

Pseudomonas aeruginosa

0 references

cystic fibrosis

0 references

author name string

B E Britigan

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

M A Railsback

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

C D Cox

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

language of work or name

0 references

publication date

1 March 1999

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

Infection and Immunity

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

67

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1207-1212

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10024562%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

On the biosynthesis of pyocyanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

The serpin superfamily of proteinase inhibitors: structure, function, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Proteins of the cystic fibrosis respiratory tract. Fragmented immunoglobulin G opsonic antibody causing defective opsonophagocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Mechanism of the antibiotic action pyocyanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Bactericidal activity of aerobic and anaerobic polymorphonuclear neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Role of pyocyanin in the acquisition of iron from transferrin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

The imbalance between granulocyte neutral proteases and antiproteases in bronchial secretions from patients with cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Pathogenesis of the pseudomonas lung lesion in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese-cofactored superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Serine Proteases: Structure and Mechanism of Catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

12 September 2017

Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Protease cleavage of iron-transferrin augments pyocyanin-mediated endothelial cell injury via promotion of hydroxyl radical formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

The formation and biologic significance of phagocyte-derived oxidants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Human plasma proteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Role of Pseudomonas aeruginosa exoenzymes in lung infections of patients with cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Enzymatic inactivation of human alpha-1-proteinase inhibitor by neutrophil myeloperoxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

14 September 2017

Pseudomonas pyocyanine alters calcium signaling in human airway epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

25 September 2017

Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

25 September 2017

The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

25 September 2017

Superoxide production by the mycobacterial and pseudomonad quinoid pigments phthiocol and pyocyanine in human lung cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

25 September 2017

Opportunities for the use of aerosolized alpha 1-antitrypsin for the treatment of cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

25 September 2017

An electron spin resonance study of oxyradical generation in superoxide dismutase- and catalase-deficient mutants of Escherichia coli K-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

15 June 2018

Inhibitory characteristics and oxidant resistance of site specific variants of recombinant human antileukoproteinase (ALP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=96448

15 June 2018

Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cytosolic inhibitor of human neutrophil elastase and cathepsin G

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of neutrophil elastase in chronic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of bacterial proteases in the pathogenesis of cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of oxidative processes in emphysema

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Neutrophil Elastase Does not Bind to Alpha1-Protease Inhibitor that Has Been Exposed to Activated Human Neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radical production from the aerobic oxidation of reduced pyridine nucleotides catalysed by phenazine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granulocyte neutral proteases and Pseudomonas elastase as possible causes of airway damage in patients with cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inactivation of alpha-1-proteinase inhibitor by gas-phase cigarette smoke: protection by antioxidants and reducing species

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10024562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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