(Q39521004)

12 September 2017

title

Pharmacological enhancement of ex vivo gene therapy neuroprotection in a rodent model of retinal degeneration (English)

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12 September 2017

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Kevin Gregory-Evans

1

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12 September 2017

Kelvin Po

series ordinal

2

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12 September 2017

Francis Chang

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3

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12 September 2017

Cheryl Y Gregory-Evans

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4

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12 September 2017

publication date

21 June 2011

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12 September 2017

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12 September 2017

volume

47

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12 September 2017

issue

1

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12 September 2017

page(s)

32-38

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Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease

12 September 2017

cites work

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Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa.

21 January 2018

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Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors

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Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration

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21 January 2018

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Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

21 January 2018

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Effect of gene therapy on visual function in Leber's congenital amaurosis

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Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant

21 January 2018

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21 January 2018

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Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma.

21 January 2018

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Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned

21 January 2018

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Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa.

21 January 2018

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Intravitreous delivery of the corticosteroid fluocinolone acetonide attenuates retinal degeneration in S334ter-4 rats

21 January 2018

1 reference

Pharmaceuticals targeting nonsense mutations in genetic diseases: progress in development

21 January 2018

1 reference

Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant.

21 January 2018

1 reference

Gene therapy: can neural stem cells deliver?

21 January 2018

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Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors

21 January 2018

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Neuroprotection in the juvenile rat model of light-induced retinopathy: evidence suggesting a role for FGF-2 and CNTF.

21 January 2018

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Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.

21 January 2018

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PTC124 targets genetic disorders caused by nonsense mutations

21 January 2018

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GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

21 January 2018

1 reference

Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration

21 January 2018

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In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration

21 January 2018

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Sustained secretion of ciliary neurotrophic factor to the vitreous, using the encapsulated cell therapy-based NT-501 intraocular device.

21 January 2018

1 reference

Identification and characterization of rod-derived cone viability factor

21 January 2018

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Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation

21 January 2018

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Drug delivery through the sclera: effects of thickness, hydration, and sustained release systems

21 January 2018

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Growth factors in combination, but not individually, rescue rd mouse photoreceptors in organ culture

21 January 2018

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Selected combination of neurotrophins potentiate neuroprotection and functional recovery following spinal cord injury in the rat.

21 January 2018

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Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF).

21 January 2018

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An experimental platform for systemic drug delivery to the retina.

21 January 2018

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Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous

21 January 2018

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Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost.

21 January 2018

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Triple agent immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome

21 January 2018

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Neurotrophic factors minimize the retinal toxicity of verteporfin photodynamic therapy

21 January 2018

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Preventing blindness in retinal disease: ciliary neurotrophic factor intraocular implants

21 January 2018

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Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000325730

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12 September 2017

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