(Q39528313)

12 September 2017

title

Loss of PTEN expression by dermal fibroblasts causes skin fibrosis (English)

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ORCID Public Data File 2021

12 September 2017

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author name string

Sunil K Parapuram

1

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12 September 2017

Xu Shi-wen

2

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12 September 2017

Christopher Elliott

3

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12 September 2017

Ian D Welch

4

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12 September 2017

Helen Jones

5

1 reference

12 September 2017

Murray Baron

6

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12 September 2017

Christopher P Denton

7

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12 September 2017

David J Abraham

8

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12 September 2017

Andrew Leask

9

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12 September 2017

language of work or name

English

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publication date

9 June 2011

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Journal of Investigative Dermatology

12 September 2017

published in

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12 September 2017

volume

131

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12 September 2017

issue

10

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12 September 2017

page(s)

1996-2003

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https://scigraph.springernature.com/pub.10.1038/jid.2011.156

12 September 2017

exact match

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cites work

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

A myocardial lineage derives from Tbx18 epicardial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

The PKB/AKT pathway in cancer

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Possible strategies for anti-fibrotic drug intervention in scleroderma

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Rac1 expression by fibroblasts is required for tissue repair in vivo

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Role of Rac1 in a bleomycin‐induced scleroderma model using fibroblast‐specific Rac1‐knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Phosphatidylinositol-3-Kinase/Akt regulates bleomycin-induced fibroblast proliferation and collagen production

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Rac inhibition reverses the phenotype of fibrotic fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

PPARgamma, PTEN, and the Fight against Cancer

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Noncanonical transforming growth factor beta signaling in scleroderma fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Biological role of phosphatase PTEN in cancer and tissue injury healing

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Post-transcriptional and post-translational regulation of PTEN by transforming growth factor-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2011.156

7 January 2021

Identifiers

DOI

10.1038/JID.2011.156

1 reference

12 September 2017

1 reference