(Q39552847)

13 September 2017

title

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel (English)

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13 September 2017

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13 September 2017

Toshana L Foster

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Richard Foster

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Richard Foster

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Colin W G Fishwick

object named as

Colin Fishwick

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Mark Verow

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object named as

Mark Verow

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13 September 2017

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Steven A Weinman

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13 September 2017

Ann L Wozniak

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13 September 2017

Matthew J Bentham

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13 September 2017

Joseph Thompson

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13 September 2017

Elizabeth Atkins

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13 September 2017

language of work or name

English

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publication date

1 July 2011

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13 September 2017

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13 September 2017

volume

54

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13 September 2017

issue

1

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13 September 2017

page(s)

79-90

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Therapy of hepatitis C: from empiricism to eradication

13 September 2017

cites work

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Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

21 January 2018

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Hepatitis C Virus p7 and NS2 Proteins Are Essential for Production of Infectious Virus

21 January 2018

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Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions

21 January 2018

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Compensatory Mutations in E1, p7, NS2, and NS3 Enhance Yields of Cell Culture-Infectious Intergenotypic Chimeric Hepatitis C Virus

21 January 2018

1 reference

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

21 January 2018

1 reference

NS3 Helicase Domains Involved in Infectious Intracellular Hepatitis C Virus Particle Assembly

21 January 2018

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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

21 January 2018

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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

21 January 2018

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Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

21 January 2018

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A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

21 January 2018

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trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation

21 January 2018

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The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

21 January 2018

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The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

21 January 2018

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Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride

21 January 2018

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Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro

21 January 2018

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The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

21 January 2018

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Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production

21 January 2018

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The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences

21 January 2018

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Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

21 January 2018

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Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus

21 January 2018

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Randomised, double blind, placebo controlled trial of interferon, ribavirin, and amantadine versus interferon, ribavirin, and placebo in treatment naïve patients with chronic hepatitis C

21 January 2018

1 reference

Evaluation of amantadine in chronic hepatitis C: a meta-analysis.

21 January 2018

1 reference

Combination therapy with amantadine and interferon in naïve patients with chronic hepatitis C: meta-analysis of individual patient data from six clinical trials

21 January 2018

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Amantadine's viral kinetics in chronic hepatitis C infection

21 January 2018

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Amantadine triple therapy for non-responder hepatitis C patients. Clues for controversies (ANRS HC 03 BITRI).

21 January 2018

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Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine

21 January 2018

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Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

21 January 2018

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Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

21 January 2018

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Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo.

21 January 2018

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Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system

21 January 2018

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Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes

21 January 2018

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Determination of Pore-Lining Residues in the Hepatitis C Virus p7 Protein

21 January 2018

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NMR studies of p7 protein from hepatitis C virus

21 January 2018

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Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants

21 January 2018

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Low pH-dependent Hepatitis C Virus Membrane Fusion Depends on E2 Integrity, Target Lipid Composition, and Density of Virus Particles

21 January 2018

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A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

21 January 2018

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Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry

21 January 2018

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Protein-protein interactions: modeling the hepatitis C virus ion channel p7.

21 January 2018

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Structural basis for the function and inhibition of an influenza virus proton channel

21 January 2018

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Structure and mechanism of the M2 proton channel of influenza A virus

21 January 2018

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Mechanism of drug inhibition and drug resistance of influenza A M2 channel

21 January 2018

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Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

21 January 2018

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Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

21 January 2018

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NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

21 January 2018

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Subcellular Localization and Topology of the p7 Polypeptide of Hepatitis C Virus

21 January 2018

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Telaprevir and peginterferon with or without ribavirin for chronic HCV infection

21 January 2018

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Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/HEP.24371

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13 September 2017

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