(Q39559758)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26148704%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26148704%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author

Swaminathan Padmanabhan

6

1 reference

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18 February 2020

author name string

S G T Devaraj

1

1 reference

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18 February 2020

W Fiskus

2

1 reference

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18 February 2020

B Shah

3

1 reference

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18 February 2020

J Qi

4

1 reference

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18 February 2020

B Sun

5

1 reference

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18 February 2020

S Sharma

7

1 reference

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18 February 2020

J E Bradner

8

1 reference

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18 February 2020

K N Bhalla

9

1 reference

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18 February 2020

publication date

15 June 2015

1 reference

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18 February 2020

1 reference

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18 February 2020

volume

30

1 reference

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18 February 2020

issue

2

1 reference

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18 February 2020

page(s)

504-508

1 reference

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https://scigraph.springernature.com/pub.10.1038/leu.2015.142

18 February 2020

exact match

0 references

cites work

BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

The mechanisms behind the therapeutic activity of BET bromodomain inhibition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Lead optimization of HMBA to develop potent HEXIM1 inducers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Selective inhibition of tumor oncogenes by disruption of super-enhancers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

BET domain co-regulators in obesity, inflammation and cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4809433

14 September 2017

Identifiers

DOI

10.1038/LEU.2015.142

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26148704%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

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18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26148704%20AND%20SRC:MED&resulttype=core&format=json