(Q39561256)

English

Phosphorylated insulin-like growth factor 1 receptor is implicated in resistance to the cytostatic effect of gefitinib in colorectal cancer cells

scientific article published on 9 April 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Phosphorylated insulin-like growth factor 1 receptor is implicated in resistance to the cytostatic effect of gefitinib in colorectal cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

phosphorylation

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colorectal cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

colorectal carcinoma

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based on heuristic

inferred from title

author name string

Li Yang

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Jianjun Li

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Li Ran

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Feng Pan

4

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Xiaoxin Zhao

5

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Zhenyu Ding

6

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Yuying Chen

7

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Qiuping Peng

8

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Houjie Liang

9

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

publication date

9 April 2011

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Journal of Gastrointestinal Surgery

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

15

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Europe PubMed Central

PubMed publication ID

13 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

942-957

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Critical evaluation of current treatments in metastatic colorectal cancer

1 reference

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21 January 2018

Epidermal growth factor-related peptides and their receptors in human malignancies

1 reference

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21 January 2018

EGFR and cancer prognosis

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

1 reference

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The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents.

1 reference

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21 January 2018

Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study).

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Somatic mutations of epidermal growth factor receptor in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Somatic mutations of EGFR in colorectal cancers and glioblastomas

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Responses of human colorectal tumor cells to treatment with the anti-epidermal growth factor receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Growth regulation and co-stimulation of human colorectal cancer cell lines by insulin-like growth factor I, II and transforming growth factor alpha

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Growth factor receptor interplay and resistance in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

GSK-3: tricks of the trade for a multi-tasking kinase

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

The glamour and gloom of glycogen synthase kinase-3

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

A molecular mechanism for the effect of lithium on development

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Deficient processing and activity of type I insulin-like growth factor receptor in the furin-deficient LoVo-C5 cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

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The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

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GSK3 takes centre stage more than 20 years after its discovery

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

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Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Glycogen synthase kinase-3: properties, functions, and regulation

1 reference

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21 January 2018

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1007%2FS11605-011-1504-Z

21 January 2018

Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of insulin-like growth factor-1 receptor in human colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of insulinlike growth factor I receptors in human colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I receptor gene structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gefitinib and irinotecan in patients with fluoropyrimidine-refractory, irinotecan-naive advanced colorectal cancer: a phase I-II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21479670

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11605-011-1504-Z

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

release_a4pw7qdzuzh5fli5eymcufm4lq

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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