(Q24297102)

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HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors

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HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors (English)

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phosphorylation

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Erb-b2 receptor tyrosine kinase 2

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GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

Carlos L Arteaga

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object named as

Carlos L Arteaga

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author name string

Shizhen Emily Wang

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Archana Narasanna

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Marianela Perez-Torres

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Bin Xiang

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Frederick Y Wu

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Seungchan Yang

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Graham Carpenter

7

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Adi F Gazdar

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Senthil K Muthuswamy

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language of work or name

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publication date

July 2006

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10

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1

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25-38

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Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?

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Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions

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