(Q36251934)

13 August 2017

1 reference

title

Modelling glandular epithelial cancers in three-dimensional cultures (English)

1 reference

13 August 2017

Jayanta Debnath

1

0 references

Joan Brugge

series ordinal

2

object named as

Joan S Brugge

1 reference

13 August 2017

language of work or name

English

0 references

publication date

1 September 2005

1 reference

13 August 2017

published in

Nature Reviews Cancer

1 reference

13 August 2017

volume

5

1 reference

13 August 2017

issue

9

1 reference

13 August 2017

page(s)

675-688

1 reference

The organizing principle: microenvironmental influences in the normal and malignant breast

13 August 2017

cites work

1 reference

Opinion: Building epithelial architecture: insights from three-dimensional culture models

31 March 2020

1 reference

Morphogenesis of the polarized epithelial cell phenotype

31 March 2020

1 reference

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

31 March 2020

1 reference

Pathology of preinvasive and excellent prognosis breast cancer

31 March 2020

1 reference

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer

31 March 2020

1 reference

Molecular portraits of human breast tumours

31 March 2020

1 reference

Multiclass cancer diagnosis using tumor gene expression signatures

31 March 2020

1 reference

Gene expression profiles of human breast cancer progression

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Modeling tissue-specific signaling and organ function in three dimensions

31 March 2020

1 reference

Expression of extracellular matrix components is regulated by substratum

31 March 2020

1 reference

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

31 March 2020

1 reference

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

31 March 2020

1 reference

Tumor reversion: Correction of malignant behavior by microenvironmental cues

31 March 2020

1 reference

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium.

31 March 2020

1 reference

In vitro karyotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522.

31 March 2020

1 reference

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

31 March 2020

1 reference

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

31 March 2020

1 reference

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

31 March 2020

1 reference

Reduced expression of dystroglycan in breast and prostate cancer

31 March 2020

1 reference

Dystroglycan: emerging roles in mammary gland function

31 March 2020

1 reference

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells

31 March 2020

1 reference

CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture

31 March 2020

1 reference

Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture

31 March 2020

1 reference

Influence of microenvironment on mammary epithelial cell survival in primary culture

31 March 2020

1 reference

Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelial cyst formation

31 March 2020

1 reference

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

31 March 2020

1 reference

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.

31 March 2020

1 reference

Control of adhesion-dependent cell survival by focal adhesion kinase

31 March 2020

1 reference

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

31 March 2020

1 reference

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

31 March 2020

1 reference

Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas

31 March 2020

1 reference

Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin in a 3D model of morphogenesis

31 March 2020

1 reference

Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells

31 March 2020

1 reference

Epimorphin mediates mammary luminal morphogenesis through control of C/EBPbeta

31 March 2020

1 reference

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

31 March 2020

1 reference

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

31 March 2020

1 reference

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

31 March 2020

1 reference

Composition and formation of intercellular junctions in epithelial cells

31 March 2020

1 reference

Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras

31 March 2020

1 reference

Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect

31 March 2020

1 reference

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

31 March 2020

1 reference

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

31 March 2020

1 reference

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

31 March 2020

1 reference

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

31 March 2020

1 reference

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

31 March 2020

1 reference

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

31 March 2020

1 reference

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

31 March 2020

1 reference

The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

31 March 2020

1 reference

Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)

31 March 2020

1 reference

Loss of PALS1 expression leads to tight junction and polarity defects.

31 March 2020

1 reference

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

31 March 2020

1 reference

Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors

31 March 2020

1 reference

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

31 March 2020

1 reference

Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway

31 March 2020

1 reference

Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.

31 March 2020

1 reference

Putting tumours in context

31 March 2020

1 reference

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.

31 March 2020

1 reference

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

31 March 2020

1 reference

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

31 March 2020

1 reference

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

31 March 2020

1 reference

E-cadherin germline mutations in familial gastric cancer.

31 March 2020

1 reference

E-cadherin expression in primary carcinomas of the breast and its distant metastases

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

The TOR pathway: a target for cancer therapy

31 March 2020

1 reference

TOR, a central controller of cell growth

31 March 2020

1 reference

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

31 March 2020

1 reference

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

31 March 2020

1 reference

Tumour-cell invasion and migration: diversity and escape mechanisms

31 March 2020

1 reference

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

31 March 2020

1 reference

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

31 March 2020

1 reference

Cell migration: a physically integrated molecular process

31 March 2020

1 reference

Cell migration: integrating signals from front to back

31 March 2020

1 reference

Tumor cell locomotion: differential dynamics of spontaneous and induced migration in a 3D collagen matrix

31 March 2020

1 reference

Studying actin-dependent processes in tissue culture

31 March 2020

1 reference

Collective cell migration in morphogenesis and cancer

31 March 2020

1 reference

Hepatocyte growth factor/scatter factor induces not only scattering but also cohort migration of human colorectal-adenocarcinoma cells

31 March 2020

1 reference

Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures

31 March 2020

1 reference

Cell contact during early morphogenesis in the chick embryo

31 March 2020

1 reference

An overview of epithelio-mesenchymal transformation

31 March 2020

1 reference

Epithelial-mesenchymal transitions in tumour progression

31 March 2020

1 reference

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

31 March 2020

1 reference

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.

31 March 2020

1 reference

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

31 March 2020

1 reference

Targeting the TGF beta signaling network in human neoplasia

31 March 2020

1 reference

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

31 March 2020

1 reference

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

31 March 2020

1 reference

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

31 March 2020

1 reference

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

31 March 2020

1 reference

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells

31 March 2020

1 reference

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells

31 March 2020

1 reference

Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.

31 March 2020

1 reference

ERK and MMPs sequentially regulate distinct stages of epithelial tubule development

31 March 2020

1 reference

The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

31 March 2020

1 reference

Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1.

31 March 2020

1 reference

A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1.

31 March 2020

1 reference

Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype

31 March 2020

1 reference

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

31 March 2020

1 reference

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

31 March 2020

1 reference

Molecular characterization of the tumor microenvironment in breast cancer

31 March 2020

1 reference

A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts

31 March 2020

1 reference

Reconstruction of functionally normal and malignant human breast tissues in mice

31 March 2020

1 reference

Long-term survivors after breast cancer.

31 March 2020

1 reference

Incidence of and treatment for ductal carcinoma in situ of the breast

31 March 2020

1 reference

Histologic classification of ductal carcinoma in situ

31 March 2020

1 reference

Atypical hyperplastic lesions of the female breast. A long-term follow-up study

31 March 2020

1 reference

Epithelial proliferations of ductal type

31 March 2020

1 reference

Ductal Carcinoma in Situ of the Breast

31 March 2020

1 reference

Basement membrane complexes with biological activity

31 March 2020

1 reference

Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis

31 March 2020

1 reference

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction

31 March 2020

1 reference

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

31 March 2020

1 reference

Interrelationship of glycogen metabolism and lactose synthesis in mammary epithelial cells of mice

31 March 2020

1 reference

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

31 March 2020

1 reference

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

31 March 2020

1 reference

Fibronectin requirement in branching morphogenesis

31 March 2020

1 reference

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

31 March 2020

1 reference

Development by self-digestion: molecular mechanisms and biological functions of autophagy

31 March 2020

1 reference

Polarity reversal of inside-out thyroid follicles cultured within collagen gel: reexpression of specific functions

31 March 2020

1 reference

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

31 March 2020

1 reference

Beta1-integrin orients epithelial polarity via Rac1 and laminin

31 March 2020

1 reference

Apical surface formation in MDCK cells: regulation by the serine/threonine kinase EMK1.

31 March 2020

1 reference

Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1695

1 reference

13 August 2017

1 reference