(Q39566045)

English

Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

scientific article published on 12 March 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase (English)

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

author name string

Surya K De

1

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Elisa Barile

2

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Vida Chen

3

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

John L Stebbins

4

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Jason F Cellitti

5

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Thomas Machleidt

6

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Coby B Carlson

7

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Li Yang

8

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Russell Dahl

9

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Maurizio Pellecchia

10

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

language of work or name

0 references

publication date

12 March 2011

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Bioorganic & Medicinal Chemistry

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

2582-2588

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration

1 reference

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14 September 2017

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

1 reference

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14 September 2017

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

1 reference

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14 September 2017

Inhibitors of c-Jun N-terminal kinases: JuNK no more?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Targeting JNK for therapeutic benefit: from junk to gold?

1 reference

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14 September 2017

The protein kinase complement of the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

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Biotransformation reactions of five-membered aromatic heterocyclic rings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Drug-induced immunotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Development and validation of a genetic algorithm for flexible docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Selective interaction of JNK protein kinase isoforms with transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

14 September 2017

Identification of the critical features of a small peptide inhibitor of JNK activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

17 June 2018

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

17 June 2018

Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Identification of small-molecule inhibitors of the JIP-JNK interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Development of paramagnetic probes for molecular recognition studies in protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089059

21 August 2018

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

1 reference

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21 August 2018

Texture mapping: a new tool for molecular graphics

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21458276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BMC.2011.03.017

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

release_ckgkjkjiavegzoohade7jcnjgy

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 September 2017

ResearchGate publication ID

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