(Q39595863)

English

Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo.

scientific article published on 13 July 2016

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18 March 2020

Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone+salt-induced cardiac fibrosis in vivo (English)

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18 March 2020

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Hemanth Kumar Kandikattu

4

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18 March 2020

author name string

Srinivas Mummidi

1

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18 March 2020

Nitin A Das

2

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18 March 2020

Andrea J Carpenter

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18 March 2020

Maike Krenz

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18 March 2020

Ulrich Siebenlist

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18 March 2020

Anthony J Valente

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18 March 2020

Bysani Chandrasekar

8

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18 March 2020

publication date

14 July 2016

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18 March 2020

Journal of Molecular and Cellular Cardiology

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18 March 2020

98

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18 March 2020

95-102

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18 March 2020

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus

1 reference

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7 January 2021

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

1 reference

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7 January 2021

Act1, an NF-kappa B-activating protein

1 reference

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7 January 2021

CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in the differentiation and survival processes of nerve cells

1 reference

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7 January 2021

Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb)

1 reference

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7 January 2021

The inflammatory response in myocardial injury, repair, and remodelling.

1 reference

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7 January 2021

View from the heart: cardiac fibroblasts in development, scarring and regeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Angiotensin II upregulates protein phosphatase 2Cα and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Interleukin-17A Is Dispensable for Myocarditis but Essential for the Progression to Dilated Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

The effect of daily administration of IL-18 on cardiac structure and function.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Effects of interleukin-18 on cardiac fibroblast function and gene expression

1 reference

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7 January 2021

Evolving role for mineralocorticoid receptor antagonists in heart failure with preserved ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Role of a selective aldosterone blocker in mice with chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Natriuretic peptides inhibit DNA synthesis in cardiac fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macroph

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress

1 reference

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7 January 2021

The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

C/EBP transcription factors regulate NADPH oxidase in human aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

Activation of AP-1 contributes to the beta-adrenoceptor-mediated myocardial induction of interleukin-6.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.07.006

7 January 2021

A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation

1 reference

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7 January 2021

Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis

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7 January 2021

Identifiers

10.1016/J.YJMCC.2016.07.006

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27423273%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27423273%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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