(Q39597217)

13 September 2017

Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

main subject

endoplasmic reticulum

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

author name string

Christine Wilson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

Michael W Finn

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

Tianhong Wang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

Alan M Krensky

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

Carol Clayberger

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

language of work or name

English

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publication date

4 February 2011

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13 September 2017

Journal of Immunology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

volume

186

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

page(s)

3497-3504

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

13 May 2020

cites work

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12 December 2020

Intracellular mediators of granulysin-induced cell death

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12 December 2020

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control

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12 December 2020

Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7

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12 December 2020

Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules

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12 December 2020

Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway

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12 December 2020

Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs

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12 December 2020

An antimicrobial activity of cytolytic T cells mediated by granulysin

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12 December 2020

Human and murine granzyme B exhibit divergent substrate preferences

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12 December 2020

Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins

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12 December 2020

Granulysin crystal structure and a structure-derived lytic mechanism

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12 December 2020

The isolation and sequence of a novel gene from a human functional T cell line

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12 December 2020

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

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12 December 2020

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

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12 December 2020

Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

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12 December 2020

Executioner caspase-3 and caspase-7 are functionally distinct proteases

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12 December 2020

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

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12 December 2020

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

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12 December 2020

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

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12 December 2020

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

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12 December 2020

Granulysin-mediated tumor rejection in transgenic mice

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12 December 2020

T-cell release of granulysin contributes to host defense in leprosy.

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12 December 2020

A new quantitative assay for cytochrome c release in apoptotic cells.

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12 December 2020

Association of mammalian cell death with a specific endonucleolytic degradation of DNA

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12 December 2020

A distinct pathway of cell-mediated apoptosis initiated by granulysin

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12 December 2020

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

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12 December 2020

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

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12 December 2020

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

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12 December 2020

Characterization of bovine homologues of granulysin and NK-lysin

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12 December 2020

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

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12 December 2020

A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

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12 December 2020

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

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12 December 2020

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

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12 December 2020

Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer

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12 December 2020

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

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12 December 2020

A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS).

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12 December 2020

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

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12 December 2020

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

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12 December 2020

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

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12 December 2020

Molecular cloning and characterization of equine NK-lysin

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12 December 2020

Decreased serum granulysin levels in childhood tuberculosis which reverse after therapy

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12 December 2020

Immune function in mice lacking the perforin gene

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12 December 2020

Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways.

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1003409

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6959523&resulttype=core&format=json

13 May 2020

1 reference