(Q35136000)

6 August 2017

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title

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal (English)

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Gene Ontology release 2020-05-02

6 August 2017

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Judy Lieberman

1

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PubMed ID

12766758

6 August 2017

language of work or name

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1 May 2003

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Nature Reviews Immunology

6 August 2017

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6 August 2017

3

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6 August 2017

361-370

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6 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nri1083

6 August 2017

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cites work

Lymphocyte-mediated cytotoxicity.

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

31 March 2020

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Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection

31 March 2020

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Delivering the kiss of death

31 March 2020

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Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

31 March 2020

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The immunological synapse.

31 March 2020

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The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

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Signaling takes shape in the immune system

31 March 2020

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The human natural killer cell immune synapse

31 March 2020

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Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

31 March 2020

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Assembly of the immunological synapse for T cells and NK cells

31 March 2020

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Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue

31 March 2020

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

31 March 2020

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Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

31 March 2020

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The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

31 March 2020

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Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

31 March 2020

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The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation

31 March 2020

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Granzyme A is an interleukin 1 beta-converting enzyme

31 March 2020

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The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin.

31 March 2020

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Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

31 March 2020

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Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.

31 March 2020

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Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

31 March 2020

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Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin

31 March 2020

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Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

31 March 2020

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The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes

31 March 2020

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Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules

31 March 2020

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Perforin lytic activity is controlled by calreticulin

31 March 2020

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Calreticulin, a component of the endoplasmic reticulum and of cytotoxic lymphocyte granules, regulates perforin-mediated lysis in the hemolytic model system.

31 March 2020

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Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

31 March 2020

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Beta-chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

31 March 2020

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

31 March 2020

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Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

31 March 2020

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Do CTL kill target cells by inducing apoptosis?

31 March 2020

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Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2

31 March 2020

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Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

31 March 2020

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

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DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis

31 March 2020

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

31 March 2020

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Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

31 March 2020

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

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Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition

31 March 2020

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Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

31 March 2020

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Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells

31 March 2020

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Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

31 March 2020

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Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis

31 March 2020

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

31 March 2020

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Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

31 March 2020

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Endonuclease G is an apoptotic DNase when released from mitochondria

31 March 2020

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Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

31 March 2020

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

31 March 2020

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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

31 March 2020

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A natural killer cell granule protein that induces DNA fragmentation and apoptosis

31 March 2020

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

31 March 2020

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Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

31 March 2020

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

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Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.

31 March 2020

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Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

31 March 2020

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Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice

31 March 2020

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Long-range disruption of gene expression by a selectable marker cassette

31 March 2020

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Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

31 March 2020

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Cell death induced by granzyme C.

31 March 2020

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Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

31 March 2020

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Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

31 March 2020

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HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

31 March 2020

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

31 March 2020

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NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter

31 March 2020

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Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.

31 March 2020

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Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

31 March 2020

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Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction

31 March 2020

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Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma

31 March 2020

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Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro

31 March 2020

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The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

31 March 2020

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The restricted expression of granzyme M in human lymphocytes

31 March 2020

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Functional significance of the perforin/granzyme cell death pathway

31 March 2020

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

31 March 2020

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

31 March 2020

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

31 March 2020

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Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

31 March 2020

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Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

31 March 2020

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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

31 March 2020

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Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

31 March 2020

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Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH.

31 March 2020

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Cell death-associated translocation of plasma membrane components induced by CTL.

31 March 2020

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An antimicrobial activity of cytolytic T cells mediated by granulysin

31 March 2020

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Granulysin, a T cell product, kills bacteria by altering membrane permeability

31 March 2020

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T-cell release of granulysin contributes to host defense in leprosy.

31 March 2020

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Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes

31 March 2020

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CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism

31 March 2020

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CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15

31 March 2020

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Granulysin crystal structure and a structure-derived lytic mechanism

31 March 2020

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A distinct pathway of cell-mediated apoptosis initiated by granulysin

31 March 2020

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A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis.

31 March 2020

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Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

31 March 2020

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

31 March 2020

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The secretory synapse: the secrets of a serial killer

31 March 2020

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Neural and immunological synaptic relations

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1083

1 reference

PubMed ID

12766758

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12766758