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English
Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
scientific article published on 01 May 1999
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1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
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8 December 2019
title
Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
author name string
P J Beresford
series ordinal
1
1 reference
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Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
Z Xia
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2
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
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8 December 2019
A H Greenberg
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3
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Europe PubMed Central
PubMed ID
10367904
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
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8 December 2019
J Lieberman
series ordinal
4
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Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
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8 December 2019
publication date
1 May 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
published in
Immunity
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
volume
10
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
page(s)
585-594
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Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
cites work
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
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inferred from DOI database lookup
Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
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The isolation and characterization of a family of serine protease genes expressed in activated cytotoxic T lymphocytes
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7 January 2021
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Ultrastructural and biochemical analysis of the stress granule in chicken embryo fibroblasts
1 reference
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reference URL
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7 January 2021
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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.
1 reference
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https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
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The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1 reference
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7 January 2021
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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity
1 reference
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Crossref
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7 January 2021
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Inhibition of human caspases by peptide-based and macromolecular inhibitors
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7 January 2021
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Cloning of a cDNA for a T cell-specific serine protease from a cytotoxic T lymphocyte
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphocyte granule-mediated cytolysis requires serine protease activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
1 reference
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reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
NAP-I is a functional homologue of TAF-I that is required for replication and transcription of the adenovirus genome in a chromatin-like structure
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multi-step chromatin degradation in apoptosis. DNA breakdown in apoptosis
1 reference
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7 January 2021
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inferred from DOI database lookup
Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers
1 reference
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7 January 2021
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inferred from DOI database lookup
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
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inferred from DOI database lookup
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Template activating factor-I remodels the chromatin structure and stimulates transcription from the chromatin template
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
A novel serine esterase expressed by cytotoxic T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
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7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mechanism of cell-mediated cytotoxicity. III. Protease-specific inhibitors preferentially block later events in cytotoxic T lymphocyte-mediated lysis than do inhibitors of methylation or thiol-reactive agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 and the regulation of programmed cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Fas(Apo-1/CD95)- and perforin-mediated lytic pathways of primary cytotoxic T lymphocytes by the protooncogene bcl-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granule-mediated killing: pathways for granzyme B-initiated apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CrmA, a poxvirus-encoded serpin, inhibits cytotoxic T-lymphocyte-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional genomics Double-stranded RNA poses puzzle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Processing and activation of pro-interleukin-16 by caspase-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980058-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-7613(00)80058-8
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
PubMed ID
10367904
1 reference
stated in
Europe PubMed Central
PubMed ID
10367904
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10367904%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 December 2019
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