(Q43559280)

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Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

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Europe PubMed Central

PubMed publication ID

24 November 2017

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

James C Whisstock

2

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Philip E. Thompson

6

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Europe PubMed Central

PubMed publication ID

24 November 2017

author name string

Sun J

1

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Harriott P

3

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Europe PubMed Central

PubMed publication ID

24 November 2017

Walker B

4

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Novak A

5

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Smith AI

7

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Europe PubMed Central

PubMed publication ID

24 November 2017

Bird PI

8

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Europe PubMed Central

PubMed publication ID

24 November 2017

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publication date

1 February 2001

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Europe PubMed Central

PubMed publication ID

24 November 2017

number of pages

8

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Journal of Biological Chemistry

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Europe PubMed Central

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24 November 2017

276

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Europe PubMed Central

PubMed publication ID

24 November 2017

18

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Europe PubMed Central

PubMed publication ID

24 November 2017

15177-15184

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Definition and redesign of the extended substrate specificity of granzyme B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

An atlas of serpin conformations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Expression and purification of recombinant human granzyme B from Pichia pastoris

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Serpins are suicide substrates: implications for the regulation of proteolytic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Structure of a serpin-protease complex shows inhibition by deformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Influence of the P5 Residue on α1-Proteinase Inhibitor Mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Human plasma proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

What do dysfunctional serpins tell us about molecular mobility and disease?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Sequence requirements in the reactive-center loop of plasminogen-activator inhibitor-1 for recognition of plasminogen activators.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Catalytic properties of the caspases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M006645200

21 January 2018

Identifiers

10.1074/JBC.M006645200

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

ResearchGate publication ID

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