(Q32003176)

5 July 2017

title

Definition and redesign of the extended substrate specificity of granzyme B. (English)

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5 July 2017

3

Hudig D

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author name string

Harris JL

1

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5 July 2017

Peterson EP

2

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5 July 2017

Thornberry NA

4

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5 July 2017

Craik CS

5

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5 July 2017

language of work or name

English

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publication date

1 October 1998

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Journal of Biological Chemistry

5 July 2017

published in

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5 July 2017

volume

273

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5 July 2017

issue

42

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5 July 2017

page(s)

27364-27373

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Execution and suicide: cytotoxic lymphocytes enforce Draconian laws through separate molecular pathways

5 July 2017

cites work

1 reference

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Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

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On the size of the active site in proteases. I. Papain

21 January 2018

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Caspases: killer proteases

21 January 2018

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Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

21 January 2018

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Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

21 January 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

21 January 2018

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Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae

21 January 2018

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Efficient selection of phleomycin-resistant Saccharomyces cerevisiae transformants.

21 January 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

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Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

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Calculation of protein extinction coefficients from amino acid sequence data

21 January 2018

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Determination of the operational molarity of solutions of bovine α-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration

21 January 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

21 January 2018

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

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The structure of rat mast cell protease II at 1.9-A resolution

21 January 2018

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Converting trypsin to chymotrypsin: the role of surface loops

21 January 2018

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Substrate phage: selection of protease substrates by monovalent phage display

21 January 2018

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A survey of furin substrate specificity using substrate phage display

21 January 2018

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Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

21 January 2018

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Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

21 January 2018

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Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.

21 January 2018

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Conversion of the substrate specificity of mouse proteinase granzyme B

21 January 2018

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The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

21 January 2018

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

21 January 2018

1 reference

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ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

21 January 2018

1 reference

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

21 January 2018

1 reference

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Cleavage of caspase family members by granzyme B: a comparative study in vitro

21 January 2018

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New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.42.27364

1 reference

5 July 2017

1 reference