(Q33857517)

29 July 2017

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title

Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors (English)

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29 July 2017

2

D Hudig

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author name string

C M Kam

series ordinal

1

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PubMed ID

10708866

29 July 2017

J C Powers

series ordinal

3

1 reference

PubMed ID

10708866

29 July 2017

language of work or name

English

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publication date

1 March 2000

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Biochimica et Biophysica Acta

29 July 2017

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29 July 2017

1477

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29 July 2017

307-323

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29 July 2017

1-2

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Human T-lymphocyte serine proteases (granzymes) 1, 2, and 3 mediated DNA fragmentation in susceptible target cells

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Degranulating cytotoxic lymphocytes inflict multiple damage pathways on target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cytotoxic T lymphocyte mediated cytolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzymes: exogenous proteinases that induce target cell apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

1 reference

7 January 2021

Homology of perforin to the ninth component of complement (C9).

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Perforin: structure, function, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Lymphocyte granule-mediated cytolysis requires serine protease activity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A natural killer cell granule protein that induces DNA fragmentation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Structure and evolutionary origin of the human granzyme H gene

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

An unusual specificity in the activation of neutrophil serine proteinase zymogens

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A novel serine proteinase (HuTSP) isolated from a cloned human CD8+ cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cloning of cDNA for granzyme-like protein III, a novel serine proteinase from rat duodenum.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

cDNA cloning of granzyme J.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Structural basis of substrate specificity in the serine proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Conversion of the substrate specificity of mouse proteinase granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Definition and redesign of the extended substrate specificity of granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Peptide thioester substrates for serine peptidases and metalloendopeptidases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granule-mediated killing: pathways for granzyme B-initiated apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzyme A is an interleukin 1 beta-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Coordinate secretion and functional synergism of T cell-associated serine proteinase-1 (MTSP-1) and endoglycosidase(s) of activated T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Deciphering the apoptotic pathway: all roads lead to death

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Direct evidence for the presence of histidine in the active center of chymotrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Evidence for the involvement of a T-cell-associated serine protease (TSP-1) in cell killing

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Irreversible inhibition of serine proteases by peptide derivatives of (alpha-aminoalkyl)phosphonate diphenyl esters

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Amino acid and peptide phosphonate derivatives as specific inhibitors of serine peptidases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Selective isocoumarin serine protease inhibitors block RNK-16 lymphocyte granule-mediated cytolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme B.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Proteases and lymphocyte cytotoxic killing mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Activation of pro-urokinase by the human T cell-associated serine proteinase HuTSP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Pro-caspase-3 is a major physiologic target of caspase-8.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Inhibition of lymphocyte protease granzyme A by antithrombin III

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Inhibition of cytotoxic T-lymphocyte-triggered apoptosis by target cell surface-coupled aprotinin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

Ecotin: lessons on survival in a protease-filled world

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900282-4

7 January 2021

10.1016/S0167-4838(99)00282-4

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10708866