(Q39627661)

13 September 2017

title

Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers (English)

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13 September 2017

J M Luke

1

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13 September 2017

J M Vincent

2

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13 September 2017

S X Du

3

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13 September 2017

U Gerdemann

4

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13 September 2017

A M Leen

5

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13 September 2017

R G Whalen

6

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13 September 2017

C P Hodgson

7

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13 September 2017

J A Williams

8

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13 September 2017

publication date

25 November 2010

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13 September 2017

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13 September 2017

volume

18

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13 September 2017

issue

4

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13 September 2017

page(s)

334-343

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https://scigraph.springernature.com/pub.10.1038/gt.2010.149

13 September 2017

exact match

0 references

cites work

Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells

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Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments

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Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system

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Plasmid DNA vaccine vector design: impact on efficacy, safety and upstream production

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Generic plasmid DNA production platform incorporating low metabolic burden seed-stock and fed-batch fermentation processes.

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Plasmid DNA production combining antibiotic-free selection, inducible high yield fermentation, and novel autolytic purification

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Detection of integration of plasmid DNA into host genomic DNA following intramuscular injection and electroporation

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Robust, vaccine-induced CD8(+) T lymphocyte response against an out-of-frame epitope

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Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells

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A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates

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PKR; a sentinel kinase for cellular stress

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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

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Adenovirus VAI RNA antagonizes the RNA-editing activity of the ADAR adenosine deaminase

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Suppression of RNA interference by adenovirus virus-associated RNA.

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Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

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Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer.

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Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import

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Muscle-specific enhancement of gene expression by incorporation of SV40 enhancer in the expression plasmid

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Electroporation in combination with a plasmid vector containing SV40 enhancer elements results in increased and persistent gene expression in mouse muscle

21 January 2018

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Identification of a boundary domain adjacent to the potent human cytomegalovirus enhancer that represses transcription of the divergent UL127 promoter

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PDX1, a cellular homeoprotein, binds to and regulates the activity of human cytomegalovirus immediate early promoter

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Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes

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Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import

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TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter

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Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

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Critical design criteria for minimal antibiotic-free plasmid vectors necessary to combine robust RNA Pol II and Pol III-mediated eukaryotic expression with high bacterial production yields

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Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells

21 January 2018

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The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors

21 January 2018

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Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging

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Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein

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Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.

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Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I

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12 December 2020

Effect of single-base substitutions in the central domain of virus-associated RNA I on its function.

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12 December 2020

The double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosis

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Cryptic open reading frames in plasmid vector backbone sequences can provide highly immunogenic cytotoxic T-lymphocyte epitopes

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12 December 2020

Translation from cryptic reading frames of DNA vaccines generates an extended repertoire of immunogenic, MHC class I-restricted epitopes

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12 December 2020

The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function

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12 December 2020

Two synthetic Sp1-binding sites functionally substitute for the 21-base-pair repeat region to activate simian virus 40 growth in CV-1 cells

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12 December 2020

Progress and prospects: nuclear import of nonviral vectors

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12 December 2020

Factors influencing the efficacy, longevity, and safety of electroporation-assisted plasmid-based gene transfer into mouse muscles

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12 December 2020

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

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12 December 2020

pDNAVACCultra vector family: high throughput intracellular targeting DNA vaccine plasmids

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12 December 2020

Identifiers

DOI

10.1038/GT.2010.149

1 reference

13 September 2017

1 reference