(Q39631188)

13 September 2017

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title

Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP). (English)

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13 September 2017

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David M. J. S. Bowman

series ordinal

2

object named as

David Bowman

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13 September 2017

Alfredo Alberti

4

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ORCID Public Data File 2021

author name string

Silvia Mirandola

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1

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13 September 2017

Mahmood M Hussain

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3

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13 September 2017

language of work or name

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23 February 2010

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13 September 2017

Nutrition and Metabolism

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13 September 2017

7

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13 September 2017

13

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https://scigraph.springernature.com/pub.10.1186/1743-7075-7-13

13 September 2017

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cites work

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14 September 2017

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Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation

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Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus

14 September 2017

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Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress

14 September 2017

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Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

14 September 2017

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Production of Infectious Hepatitis C Virus of Various Genotypes in Cell Cultures

14 September 2017

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Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

14 September 2017

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Hepatitis C and insulin resistance: steatosis, fibrosis and non-response

14 September 2017

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STEATOSIS IN CHRONIC HEPATITIS C: WHY DOES IT REALLY MATTER?

14 September 2017

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14 September 2017

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Hepatitis C virus nonstructural proteins inhibit apolipoprotein B100 secretion

14 September 2017

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Steatosis and chronic hepatitis C virus infection: mechanisms and significance.

14 September 2017

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A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Hepatitis C virus infection and liver steatosis

14 September 2017

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Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells

14 September 2017

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ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

14 September 2017

1 reference

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Quantitative assessment of fibrosis and steatosis in liver biopsies from patients with chronic hepatitis C

14 September 2017

1 reference

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The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

14 September 2017

1 reference

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Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators

14 September 2017

1 reference

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Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma

14 September 2017

1 reference

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Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatocyte nuclear factor (HNF) 1 and HNF4 mediate hepatic multidrug resistance protein 2 up-regulation during hepatitis C virus gene expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus infection can present with metabolic disease by inducing insulin resistance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Transcriptional regulation of human microsomal triglyceride transfer protein by hepatocyte nuclear factor-4alpha

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Histopathology of Hepatitis C Virus Infection

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Pathobiology of hepatitis C.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Histopathologic findings in chronic hepatitis C.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Insulin resistance and hepatitis C.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

The histological features of chronic hepatitis C and autoimmune chronic hepatitis: a comparative analysis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy?

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Microsomal triglyceride transfer protein (MTP) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis

21 August 2018

1 reference

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Different mechanisms of steatosis in hepatitis C virus genotypes 1 and 3 infections

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.

21 August 2018

1 reference

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Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838899

A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels

21 August 2018

1 reference

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Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis

4 November 2018

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12 December 2020

Hepatitis C and steatosis

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12 December 2020

Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis

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12 December 2020

Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C

1 reference

12 December 2020

The pathology of hepatitis C

1 reference

12 December 2020

Intranuclear particles in non-A, non-B hepatitis

1 reference

12 December 2020

Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group

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12 December 2020

Host- and disease-specific factors affecting steatosis in chronic hepatitis C

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12 December 2020

Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes

1 reference

12 December 2020

Hepatitis C and steatosis

1 reference

12 December 2020

Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients

1 reference

12 December 2020

Identifiers

DOI

10.1186/1743-7075-7-13

1 reference

Dimensions Publication ID

13 September 2017

0 references

1 reference

13 September 2017

PubMed publication ID

20178560

1 reference